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PRDM16 is necessary for sensory neuronal development in the Trigeminal Ganglion
Biorxiv : the Preprint Server for Biology
|February 12, 2026
Summary
Prdm16 is crucial for trigeminal ganglion (TG) development and sensory neuron formation in both zebrafish and mice. Loss of Prdm16 impairs TG assembly, neurogenesis, and axon projection, highlighting its role in peripheral nervous system development.
Area of Science:
- Developmental Biology
- Neuroscience
- Genetics
Background:
- Cranial neural crest cells (cNCC) form craniofacial structures and peripheral neurons.
- PRDM16 is a transcriptional regulator involved in craniofacial development.
- The role of PRDM16 in cranial sensory ganglion formation was previously undefined.
Purpose of the Study:
- To investigate the role of Prdm16 in trigeminal ganglion (TG) development and sensory neurogenesis.
- To determine if Prdm16 is conserved in TG development across species.
Main Methods:
- Zebrafish and mouse models were used to study Prdm16 function.
- Loss-of-function studies involved genetic manipulation of Prdm16.
- Immunohistochemistry, live imaging, and transcriptomic analysis were employed to assess TG development and neurogenesis.
Main Results:
- Prdm16 is expressed in the developing TG in both zebrafish and mice.
- Prdm16 loss-of-function resulted in reduced TG size, fewer sensory neurons, and altered axon projections.
- Transcriptomic analysis revealed reduced expression of neurogenic genes in Prdm16-deficient cNCCs.
Conclusions:
- Prdm16 is essential for TG assembly and sensory neuron differentiation.
- Prdm16 acts as a conserved regulator of peripheral sensory nervous system development.
- This study links PRDM-family chromatin regulators to the development of sensory ganglia.
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