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Related Concept Videos

Aging01:26

Aging

801
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

713
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
713
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Updated: Feb 13, 2026

Behavioral Assessment of the Aging Mouse Vestibular System
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The aging mouse lipidome.

Edgar Esparza, Steven E Pilley, Xuanyi Shi

    Biorxiv : the Preprint Server for Biology
    |February 12, 2026
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    Summary
    This summary is machine-generated.

    Aging alters the lipidome (fatty molecule composition) differently across organs and sexes. Key changes were observed in the thymus and muscle, revealing organ-specific aging patterns in mice.

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    Area of Science:

    • Gerontology
    • Metabolomics
    • Lipidomics

    Background:

    • Aging is linked to metabolic shifts impacting function and health.
    • Existing research on age-associated lipidome changes across tissues and sexes is incomplete.

    Purpose of the Study:

    • To comprehensively map age- and sex-dependent lipidome alterations across multiple organs in mice.
    • To identify specific lipid classes and tissues most affected by aging and sex.

    Main Methods:

    • Targeted lipidomics analysis of 775 lipids across 10 organs from male and female mice at five different ages.
    • Comparative analysis to identify organ-specific and sex-specific lipid changes during aging.

    Main Results:

    • Aging impacts the lipidome in an organ-specific manner, with the thymus and quadriceps muscle showing the most significant changes.
    • Quadriceps muscle showed decreased phosphatidylcholine and phosphatidylethanolamine lipids, particularly those with adrenic acid, with age.
    • Spleens exhibited sex-dependent lipid differences, with females having lower lysophosphatidylcholine and lysophosphatidylethanolamine levels than males.

    Conclusions:

    • This study provides a detailed atlas of age- and sex-associated lipid changes in mouse organs.
    • Findings complement existing resources, aiding further research into aging mechanisms and metabolic health.