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Purification of a High Molecular Mass Protein in Streptococcus mutans
Published on: September 14, 2019
Association between Oral Streptococcus Mutans Counts and Proteinuria in Patients with Chronic Kidney Disease: A Pilot
Taro Misaki1,2,3, Yuto Suehiro3,4, Shuhei Naka5
1Division of Nephrology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka, Japan.
Introduction:
Chlorhexidine mouthwash is one of the most widely used anti-microbial agents, reducing oral cavity bacterial load. However, the effects of mouthwash on systemic conditions in patients with chronic kidney disease (CKD) remain unknown. We examined the relationship between Streptococcus mutans abundance in the oral cavity and proteinuria in patients with CKD.
Methods:
Patients with CKD (n = 57) gargled with mouthwash containing chlorhexidine gluconate three times daily for 1 year. We prospectively investigated the relationship between changes in the number of S. mutans and proteinuria.
Results:
The number of S. mutans colony-forming units (CFU) ≥103/mL saliva at month 0 was significantly associated with higher urinary proteinuria and S. mutans CFU/mL over time. The mean number of S. mutans in all patients decreased significantly after 12 months. Proteinuria also decreased significantly after 12 months compared with after 6 months. The rate of proteinuria <0.3 g/g creatinine after 12 months was significantly higher in the group that had <103 CFU/mL S. mutans after 12 months than in other groups.
Conclusions:
In this pilot study, a potential association was observed between oral S. mutans counts and proteinuria in patients with CKD. Larger studies are needed to clarify this relationship.
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