Related Experiment Video

Updated: Feb 13, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

10.2K

Differential Impact of Allergen Sensitization on Asthma Development in High-Risk Japanese Infants with Atopic

Sayaka Hamaguchi1,2, Kotaro Umezawa1, Kenji Toyokuni1

  • 1Allergy Center, National Center for Child Health and Development, Tokyo, Japan.

JMA Journal
|February 12, 2026
PubMed

Insights

Peanut sensitization in infancy is a strong predictor of asthma development in Japanese children with atopic dermatitis (AD). Early allergen testing can identify high-risk children for targeted asthma prevention.

Area of Science:

  • Pediatric Allergy and Immunology
  • Dermatology
  • Pulmonology

Background:

  • The atopic march describes the progression of allergic diseases from early eczema to food allergies and asthma.
  • While atopic dermatitis (AD) is linked to allergic diseases in Japanese children, the role of peanut sensitization, a known asthma risk factor in Western populations, remains unclear due to its lower prevalence.

Purpose of the Study:

  • To evaluate if peanut sensitization predicts asthma development in Japanese children with AD.
  • To compare the predictive value of peanut sensitization against other common allergens for asthma development.

Main Methods:

  • A retrospective cohort study of 203 children under age two with physician-diagnosed AD was conducted.
  • Simultaneous measurement of specific immunoglobulin E to egg white, peanut, and house dust mite was performed.
  • Participants were followed until age six, with asthma development analyzed using logistic regression and decision tree analysis.

Main Results:

  • Asthma developed in 32.0% of participants.
  • Peanut sensitization was significantly more common in the asthma group (53.8% vs. 29.7%, p = 0.001).
  • Decision tree analysis identified peanut sensitization as the most influential predictor of asthma, especially when combined with allergic rhinitis.

Conclusions:

  • Peanut sensitization in infancy is a strong predictor of asthma in Japanese children with AD.
  • Early allergen-specific sensitization profiling can aid in identifying high-risk children.
  • This approach supports the development of targeted asthma prevention strategies.
Abstract

Keywords:
House dust miteIgE sensitizationasthmaatopic dermatitisegg whitepeanut

More Related Videos

Murine Model of Allergen Induced Asthma08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

41.3K
Exploring Infant Sensitivity to Visual Language using Eye Tracking and the Preferential Looking Paradigm06:07

Exploring Infant Sensitivity to Visual Language using Eye Tracking and the Preferential Looking Paradigm

Published on: May 15, 2019

9.1K

Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.5K
Sensitivity, Specificity, and Predicted Value01:13

Sensitivity, Specificity, and Predicted Value

In healthcare diagnostics, laboratory tests play a crucial role in identifying and diagnosing a wide range of medical conditions. However, interpreting test results is not always straightforward. An abnormal test result does not always confirm the presence of a disease, just as a normal result does not guarantee its absence. To assess the reliability of these diagnostic tools, healthcare practitioners rely on two key statistical indicators: sensitivity and specificity.
Sensitivity is the...
1.4K
Sputum Studies II: Culture and Sensitivity01:20

Sputum Studies II: Culture and Sensitivity

Description
Sputum culture and sensitivity is a medical procedure used to diagnose bacterial infections in the respiratory tract and select the most appropriate antibiotics for treatment. This process involves analyzing sputum samples of thick and opaque secretions produced in the lungs and airways. These samples are collected from patients and then sent to the laboratory for analysis.
The test can identify various pathogens responsible for respiratory infections, including Streptococcus,...
1.3K
Urine Studies II: Urine Culture and Sensitivity Test01:26

Urine Studies II: Urine Culture and Sensitivity Test

A urine culture and sensitivity test is a diagnostic procedure used to identify urinary tract bacterial infections and determine the most effective antibiotics for treatment. This test is generally preferred when a patient shows manifestations of a urinary tract infection, such as frequent or painful urination, cloudy or foul-smelling urine, or lower abdominal pain.Purpose of the TestThe primary goals of a urine culture and sensitivity test are to:Determine the specific bacteria causing the...
1.3K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.4K