Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

2.9K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.9K
Peptide Bonds02:43

Peptide Bonds

83.5K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
83.5K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

53.7K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
53.7K
Bacterial Signaling01:30

Bacterial Signaling

41.3K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
41.3K
Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

4.3K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.3K
Therapeutic Index01:13

Therapeutic Index

6.9K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reinforcing the Arsenal: Advanced Antibiotic Adjuvants as Strategic Disruptors of Bacterial Defenses.

Journal of agricultural and food chemistry·2026
Same author

Dipiperazine-Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram-Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Evaluation of LLM-generated peptide as foundation template for discovery of effective encrypted AMPs against clinical superbugs.

Microbiology spectrum·2025
Same author

Design, Synthesis, and Bioactivity Evaluation of Novel 1-Methyl-2-phenylpyridin-1-ium Derivatives as Broad-Spectrum FtsZ Inhibitors.

Journal of agricultural and food chemistry·2025
Same author

Design, Synthesis, and Biological Evaluation of 2-Phenoxyalkylhydrazide Benzoxazole Derivatives as Quorum Sensing Inhibitors with Strong Antibiofilm Effect.

Journal of medicinal chemistry·2024
Same author

Three Rounds of Stability-Guided Optimization and Systematical Evaluation of Oncolytic Peptide LTX-315.

Journal of medicinal chemistry·2024

Related Experiment Video

Updated: Feb 13, 2026

Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens
11:18

Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens

Published on: March 15, 2012

44.6K

Host-Pathogen Interactions and Peptide-Based Therapeutics in Intracellular Bacterial Infections.

Jun Jiang1, Yunkun Qi2, Shutao Ma1

  • 1Department of Medicinal Chemistry, Shandong Key Laboratory of Druggability Optimization and Evaluation for Lead Compounds, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.

ACS Infectious Diseases
|February 12, 2026
PubMed
Summary

Peptide therapeutics offer a novel solution for persistent intracellular bacterial infections, overcoming traditional antibiotic limitations. These advanced therapies utilize precision delivery and multimodal action to combat drug resistance and enhance host defenses.

Keywords:
antimicrobial resistancecell-penetrating peptidehost−pathogen interactionsintracellular infectionpeptide-based therapy

More Related Videos

Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes
14:05

Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes

Published on: September 19, 2013

10.4K
Infection of Zebrafish Larvae with Aspergillus Spores for Analysis of Host-Pathogen Interactions
09:42

Infection of Zebrafish Larvae with Aspergillus Spores for Analysis of Host-Pathogen Interactions

Published on: May 16, 2020

4.6K

Related Experiment Videos

Last Updated: Feb 13, 2026

Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens
11:18

Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens

Published on: March 15, 2012

44.6K
Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes
14:05

Imaging InlC Secretion to Investigate Cellular Infection by the Bacterial Pathogen Listeria monocytogenes

Published on: September 19, 2013

10.4K
Infection of Zebrafish Larvae with Aspergillus Spores for Analysis of Host-Pathogen Interactions
09:42

Infection of Zebrafish Larvae with Aspergillus Spores for Analysis of Host-Pathogen Interactions

Published on: May 16, 2020

4.6K

Area of Science:

  • Microbiology
  • Immunology
  • Drug Discovery

Background:

  • Intracellular bacterial infections pose significant global health challenges due to their persistence.
  • Understanding host-pathogen interactions is key to developing effective treatments.
  • Conventional antibiotics often fail against intracellular bacteria because of resistance mechanisms like poor permeability and efflux.

Purpose of the Study:

  • To review host-pathogen interactions in intracellular bacterial infections.
  • To explore peptide-based therapeutics as a novel strategy against these infections.
  • To discuss strategies for optimizing and translating these therapeutics for clinical use.

Main Methods:

  • Review of current literature on host-pathogen interactions and intracellular bacteria.
  • Analysis of peptide-based therapeutic approaches, including cell-penetrating peptides (CPPs).
  • Discussion of drug delivery optimization, resistance mitigation, and host-directed therapy strategies.

Main Results:

  • Peptide therapeutics offer precision delivery via CPPs and multimodal bactericidal mechanisms to overcome resistance.
  • Host-directed therapies can reactivate innate immune pathways.
  • AI-driven discovery and rational chemical design are highlighted for optimization.

Conclusions:

  • Peptide-based drugs represent a promising frontier for treating intracellular bacterial infections.
  • Future directions include ultralarge library screening, advanced formulation (e.g., nanoencapsulation), and stimuli-responsive delivery systems.
  • Compartment-specific pharmacokinetic/pharmacodynamic (PK/PD) models are crucial for assessing therapeutic efficacy.