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Peculiar Cat with Many Lives: PUMA in Viral Infections.
Zbigniew Wyżewski1, Justyna Stępkowska2, Pola Pruchniak3
1Institute of Biological Sciences, Cardinal Stefan Wyszynski University in Warsaw, Dewajtis 5, 01-815 Warsaw, Poland.
Cells
|February 12, 2026
Summary
The p53-upregulated modulator of apoptosis (PUMA) plays a dual role in viral infections, either aiding or hindering viral spread. Viruses strategically manipulate PUMA to control host cell death for their benefit.
Area of Science:
- Cellular biology
- Virology
- Immunology
Background:
- Apoptosis is crucial for tissue homeostasis and is implicated in viral infections.
- The p53-up-regulated modulator of apoptosis (PUMA) is a key regulator of the intrinsic apoptotic pathway.
- PUMA's role in viral infections is complex, influencing host-pathogen interactions.
Purpose of the Study:
- To elucidate the multifaceted role of PUMA in various viral infections.
- To investigate viral strategies for modulating PUMA signaling pathways.
- To explore potential therapeutic applications targeting PUMA in viral diseases.
Main Methods:
- Literature review of studies on PUMA and viral infections.
- Analysis of molecular mechanisms by which viruses interact with PUMA.
- Examination of PUMA's impact on host cell viability during infection.
Main Results:
- PUMA can either promote or inhibit viral infection depending on the virus and host context.
- Viruses employ diverse strategies to modulate PUMA, including gene suppression, protein inactivation, or induction.
- PUMA's influence on apoptosis is a critical factor in viral pathogenesis and disease progression.
Conclusions:
- PUMA is a significant factor in the interplay between viruses and host cells.
- Understanding viral modulation of PUMA offers insights into viral pathogenesis.
- Targeting PUMA presents potential therapeutic avenues for managing viral infections and associated diseases.
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