Related Experiment Video

Updated: Feb 13, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.8K

Interest in Long-Acting PrEP by Methamphetamine Use Among Men Who Have Sex with Men in Four Western US Cities

Vanessa M McMahan1,2,3, Courtney Moreno4, Alia Al-Tayyib5

  • 1Harvard Medical School, Boston, MA, USA. Vanessa_McMahan@hphci.harvard.edu.

AIDS and Behavior
|February 12, 2026
PubMed

Insights

Interest in long-acting pre-exposure prophylaxis (PrEP) is high among men who have sex with men (MSM). Methamphetamine users showed similar interest and use but lower awareness of PrEP options.

Area of Science:

  • Public Health
  • Infectious Disease Prevention
  • Sexual Health

Background:

  • Methamphetamine use is a significant factor in HIV transmission among men who have sex with men (MSM).
  • Suboptimal adherence to daily oral pre-exposure prophylaxis (PrEP) is common among methamphetamine-using MSM.
  • Long-acting PrEP presents a potential alternative to daily oral PrEP.

Purpose of the Study:

  • To assess interest in long-acting PrEP among HIV-negative MSM.
  • To compare interest and PrEP awareness between methamphetamine users and non-users within this population.

Main Methods:

  • Analysis of data from the 2023 National HIV Behavioral Surveillance survey.
  • Inclusion of 1,450 HIV-negative MSM participants from four western cities.
  • Assessment of methamphetamine use in the past 12 months and interest in long-acting PrEP.

Main Results:

  • Two-thirds (68%) of participants expressed interest in long-acting PrEP.
  • No significant differences in interest or prior PrEP use were observed between methamphetamine users and non-users.
  • Participants unaware of PrEP were more likely to have used methamphetamine (20% vs. 7%).
  • Among interested individuals, biannual injection was the preferred method (47%).

Conclusions:

  • High interest in long-acting PrEP exists among MSM, including those who use methamphetamine.
  • Methamphetamine users demonstrated similar PrEP interest and use but lower awareness compared to non-users.
  • Targeted awareness campaigns may be needed for methamphetamine-using MSM regarding PrEP options.
Keywords:
HIV preventionLong-acting pre-exposure prophylaxisMen who have sex with menMethamphetamine

More Related Videos

Breakfast Habits among Schoolchildren in the City of Uruguaiana, Brazil06:48

Breakfast Habits among Schoolchildren in the City of Uruguaiana, Brazil

Published on: July 29, 2020

5.2K
The Fastest Western in Town: A Contemporary Twist on the Classic Western Blot Analysis11:43

The Fastest Western in Town: A Contemporary Twist on the Classic Western Blot Analysis

Published on: February 5, 2014

28.0K

Related Concept Videos

Western Blotting01:15

Western Blotting

Western blotting is an analytical technique for protein identification. It has various applications in immunology and medicine, including detecting diseases like bovine spongiform encephalopathy, mad cow disease, and human and feline immunodeficiency virus from biological samples.
The technique begins with separating proteins from the sample using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), followed by protein transfer, immunoblotting, and finally, protein detection.
21.0K
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
109.2K
Forces Acting on Chromosomes02:11

Forces Acting on Chromosomes

During mitosis, chromosome movements occur through the interplay of multiple piconewton level forces. In prometaphase, these forces help in chromosome assembly or congression at the equatorial plane, eventually leading to their alignment at the metaphase plate. The forces acting on the chromosomes are space and time-dependent; therefore, they vary with the position of the chromosomes as the cell progresses through mitosis. 
Microtubules and motor proteins exert two types of forces on...
4.0K
Direct-Acting Cholinergic Agonists: Pharmacokinetics01:31

Direct-Acting Cholinergic Agonists: Pharmacokinetics

Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
1.9K
Drugs Acting on Autonomic Ganglia: Stimulants01:23

Drugs Acting on Autonomic Ganglia: Stimulants


Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
2.1K
Drugs Acting on Autonomic Ganglia: Blockers01:28

Drugs Acting on Autonomic Ganglia: Blockers

Ganglionic blockers inhibit autonomic activity by blocking nicotinic receptors in the autonomic ganglia, suppressing impulse transmission. These blockers lack selectivity between sympathetic and parasympathetic ganglia and are ineffective as neuromuscular junction antagonists. They can be categorized into two groups:
1.7K