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Related Experiment Video

Updated: Feb 13, 2026

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Suspect List-Guided High-Throughput Screening (SLIG-HTS) Identifies Environmental Substances Associated with Advanced

Peng Wang1, Yu Li2, Ziyu Zhang1

  • 1State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.

Environmental Science & Technology
|February 12, 2026
PubMed
Summary
This summary is machine-generated.

Environmental contaminants can accelerate embryonic development, posing risks. This study identified substances, including sulfonamide antibiotics, that advance developmental timing in zebrafish at low concentrations, highlighting potential ecological concerns.

Keywords:
advanced developmental timingenvironmental contaminantshigh-throughput screeningretrospective analysissulfonamideszebrafish embryogenesis

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Area of Science:

  • Environmental toxicology
  • Developmental biology
  • Ecotoxicology

Background:

  • Environmental contaminants often retard embryonic development, but accelerated development is less studied despite its risks.
  • Understanding factors influencing developmental timing is crucial for assessing ecological impacts of chemical exposure.

Purpose of the Study:

  • To develop and apply a screening strategy to identify environmental substances that accelerate embryonic developmental timing.
  • To investigate the effects of identified compounds on zebrafish development at environmentally relevant concentrations.

Main Methods:

  • Developed a Suspect List-Guided High-Throughput Screening strategy.
  • Integrated literature-informed suspect lists with stage-resolved endpoint evaluation.
  • Retrospectively screened over 9,300 toxicity records and experimentally validated 46 suspect compounds in zebrafish.

Main Results:

  • Identified 27 compounds (58.7%) affecting zebrafish embryonic morphological endpoints.
  • Sulfonamide antibiotics sulfadiazine and sulfamethoxazole showed significant effects at ng/L to low μg/L concentrations.
  • Transcriptomic analysis revealed pathway-level shifts in neuromuscular and cardiovascular development, indicating altered developmental timing.

Conclusions:

  • The integrated approach successfully identified environmental substances, particularly sulfonamides, that advance embryonic developmental timing at relevant concentrations.
  • These findings highlight potential class-wide effects of sulfonamides and their ecological relevance.
  • Advanced embryonic development due to environmental contaminants is a significant ecotoxicological concern.