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Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
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Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy

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A bicistronic viral genome uses a compact type IV IRES near its 3' end to express a transmembrane protein

Madeline E Sherlock1, Katherine E Segar2, Jeffrey S Kieft2

  • 1New York Structural Biology Center, New York, NY 10025, USA; Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Cell Reports
|February 12, 2026
PubMed

Keywords:
CP: microbiologyCP: molecular biologyRNA structurecryo-EMinternal ribosome entry sitetranslation regulationviral RNA

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