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Dimeric Furanones with a Unique Polycyclic Spiro Skeleton from Hawk Tea
Yike Fang1,2, Yilin Wu1, Yufan Meng1,3
1Guizhou Key Laboratory of Modern Traditional Chinese Medicine Creation and School of Pharmacy, Zunyi Medical University, Zunyi 563000, China.
None:
Six novel furanone derivatives, hawktealide A-F (1-6), featuring a novel 5/6/5 tricyclic system containing with a spiro-ring, were isolated from hawk tea. The structures of these compounds were confirmed using high-resolution electrospray ionization mass spectrometry (HR-ESIMS), nuclear magnetic resonance (NMR), electronic circular dichroism (ECD), and single-crystal X-ray diffraction data. Compounds 1-3 showed concentration-dependent cytotoxicity against AsPC-1 and HCT-116 cells. Compound 1 was notably more potent against AsPC-1 cells than against HCT-116 or L02 cells. Further experiments revealed that compound 1 induced autophagy, inhibited migration, and caused cell cycle arrest in AsPC-1 cells.
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