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Engaging Artificial Intelligence (AI)-based chatbots in digital health: A systematic review
Shi Feng1, Xiufang Leah Li1, Alexandra Nicole Wake1
1School of Media and Communication, RMIT University, Melbourne, Victoria, Australia.
PLOS Digital Health
|February 12, 2026
Summary
Artificial intelligence (AI)-based chatbots offer innovative health solutions. This systematic review evaluates their applications and effectiveness, identifying key research areas and limitations for future development.
Area of Science:
- Health Informatics
- Artificial Intelligence
- Human-Computer Interaction
Background:
- The healthcare sector is increasingly adopting Artificial Intelligence (AI) solutions.
- AI-based chatbots are emerging as key tools to address health challenges.
- Deep learning architectures are driving advancements in AI healthcare applications.
Purpose of the Study:
- To systematically review existing research on AI-based chatbots in healthcare.
- To identify current applications and evaluation methods for AI chatbots.
- To address concerns regarding chatbot effectiveness and ethical implications.
Main Methods:
- Systematic literature review of 348 articles from eight major databases.
- Analysis focused on AI-based chatbots in the health domain.
- Identified four primary research areas: text quality, clinical efficacy, user engagement, and safety.
Main Results:
- AI-based chatbots are applied across four main research areas.
- A significant gap exists in the number of randomized controlled trials (RCTs).
- Limited use of theoretical frameworks hinders robust performance evaluation.
Conclusions:
- Further research is needed to optimize AI chatbot potential in healthcare.
- Addressing the lack of RCTs and theoretical frameworks is crucial for advancing chatbot development.
- Future directions should focus on enhancing clinical efficacy, user engagement, and safety while considering ethical implications.
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