Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecular Shape and Polarity03:37

Molecular Shape and Polarity

76.1K
Dipole Moment of a Molecule
76.1K
Crystal Field Theory - Tetrahedral and Square Planar Complexes02:46

Crystal Field Theory - Tetrahedral and Square Planar Complexes

48.7K
Tetrahedral Complexes
Crystal field theory (CFT) is applicable to molecules in geometries other than octahedral. In octahedral complexes, the lobes of the dx2−y2 and dz2 orbitals point directly at the ligands. For tetrahedral complexes, the d orbitals remain in place, but with only four ligands located between the axes. None of the orbitals points directly at the tetrahedral ligands. However, the dx2−y2 and dz2 orbitals (along the Cartesian axes) overlap with the ligands less than the dxy,...
48.7K
Group Polarization01:01

Group Polarization

39.2K
Group polarization is the strengthening of an original group attitude following the discussion of views within a group (Teger & Pruitt, 1967). That is, if a group initially favors a viewpoint, after discussion the group consensus is likely a stronger endorsement of the viewpoint. Conversely, if the group was initially opposed to a viewpoint, group discussion would likely lead to stronger opposition.
39.2K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

3.8K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
3.8K
Planar Rigid-Body Motion01:22

Planar Rigid-Body Motion

1.1K
Understanding the movement of a rigid body in planar motion involves recognizing that every particle within this body is traversing a path that maintains a consistent distance from a specific plane. This concept is fundamental in the study of physics and mechanical engineering, and it allows us to comprehend better how objects move in space.
Planar motion is typically divided into three distinct categories. The first is rectilinear translation, demonstrated by a subway train that moves along...
1.1K
Gauss's Law: Planar Symmetry01:27

Gauss's Law: Planar Symmetry

9.6K
A planar symmetry of charge density is obtained when charges are uniformly spread over a large flat surface. In planar symmetry, all points in a plane parallel to the plane of charge are identical with respect to the charges. Suppose the plane of the charge distribution is the xy-plane, and the electric field at a space point P with coordinates (x, y, z) is to be determined. Since the charge density is the same at all (x, y) - coordinates in the z = 0 plane, by symmetry, the electric field at P...
9.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Highly dynamic mechanical transitions in embryonic cell populations during Drosophila gastrulation.

Nature communications·2025
Same author

Microtubule competition and cell growth recenter the nucleus after anaphase in fission yeast.

bioRxiv : the preprint server for biology·2023
Same author

β-heavy-spectrin stabilizes the constricting contractile ring during cytokinesis.

The Journal of cell biology·2022
Same author

Mechanical competition alters the cellular interpretation of an endogenous genetic program.

The Journal of cell biology·2021
Same author

Polarity sorting drives remodeling of actin-myosin networks.

Journal of cell science·2018
Same author

A disassembly-driven mechanism explains F-actin-mediated chromosome transport in starfish oocytes.

eLife·2018

Related Experiment Video

Updated: Feb 14, 2026

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
07:07

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

11.0K

Start small: A model for tissue-wide planar cell polarity without morphogens.

Abhisha Thayambath1,2, Julio M Belmonte1,2

  • 1Department of Physics, North Carolina State University, Raleigh, North Carolina, United States of America.

Plos Computational Biology
|February 12, 2026
PubMed
Summary

Planar cell polarity (PCP) can be established without global cues. A new model shows local signals, small tissue size, and proliferation can achieve tissue-wide cell polarization.

More Related Videos

Planar and Three-Dimensional Printing of Conductive Inks
10:49

Planar and Three-Dimensional Printing of Conductive Inks

Published on: December 9, 2011

37.8K
An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics
09:25

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

Published on: December 24, 2015

9.4K

Related Experiment Videos

Last Updated: Feb 14, 2026

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
07:07

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

11.0K
Planar and Three-Dimensional Printing of Conductive Inks
10:49

Planar and Three-Dimensional Printing of Conductive Inks

Published on: December 9, 2011

37.8K
An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics
09:25

An Endothelial Planar Cell Model for Imaging Immunological Synapse Dynamics

Published on: December 24, 2015

9.4K

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Computational Biology

Background:

  • Planar cell polarity (PCP) is a fundamental epithelial patterning mechanism.
  • PCP guides oriented growth, cell division, and movement in development.
  • Existing models often require global cues or gradients for tissue-wide orientation.

Purpose of the Study:

  • To investigate PCP patterning without relying on global morphogen gradients.
  • To explore conditions enabling global tissue orientation via local signals.
  • To model PCP using the Cellular Potts framework.

Main Methods:

  • Cellular Potts modelling framework application.
  • Simulation of local boundary signals and uniform proliferation.
  • Analysis of cell division planes and growth rate impacts.
  • Comparison of cell-autonomous and cell non-autonomous PCP models.

Main Results:

  • Global tissue orientation achieved via local boundary signals, small initial size, and uniform proliferation.
  • Demonstrated PCP establishment independent of tissue-spanning gradients.
  • Identified influence of cell division orientation and growth rates on patterning.
  • Cell non-autonomous models showed more robust patterning without gradients.

Conclusions:

  • PCP patterning can occur without global cues, challenging existing paradigms.
  • Local interactions and specific proliferation dynamics are sufficient for long-range polarity.
  • Cell non-autonomous mechanisms enhance robustness in gradient-free PCP.