Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Resting Membrane Potential01:21

The Resting Membrane Potential

143.3K
Overview
143.3K
Mismatch Repair01:36

Mismatch Repair

43.8K
Overview
43.8K
Resting Membrane Potential01:24

Resting Membrane Potential

22.1K
The relative difference in electrical charge, or voltage, between the inside and the outside of a cell membrane, is called the membrane potential. It is generated by differences in permeability of the membrane to various ions and the concentrations of these ions across the membrane.
The Inside of a Neuron is More Negative
The membrane potential of a cell can be measured by inserting a microelectrode into a cell and comparing the charge to a reference electrode in the extracellular fluid. The...
22.1K
Resting Potential Decay01:15

Resting Potential Decay

6.5K
The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane...
6.5K
Overview of DNA Repair02:25

Overview of DNA Repair

33.9K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
33.9K
Base Excision Repair01:54

Base Excision Repair

26.5K
One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
26.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The neurobiology of survivorship: Cognitive consequences of modern oncology.

Neuro-oncology advances·2026
Same author

A prognostic human brain network for diffuse midline glioma.

Nature·2026
Same author

Intranasal Anti-CD3 Antibody Treatment Attenuates Post-COVID Neuroinflammation and Enhances Hippocampal Neurogenesis and Cognitive Function in Mice.

bioRxiv : the preprint server for biology·2026
Same author

KIF5A downregulation in spinal muscular atrophy links axonal regeneration defects with ALS.

JCI insight·2026
Same author

Berzosertib enhances the sensitivity of pediatric diffuse midline glioma H3K27-altered cells to radiotherapy.

Cell death & disease·2026
Same author

Deciphering the tumor microenvironment and role of immunotherapy in diffuse midline glioma: A scoping review.

Neuro-oncology·2026
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography
06:40

Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography

Published on: June 15, 2018

10.7K

Rest to repair.

Kamsi Nwangwu1, Michelle Monje1,2

  • 1Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA USA.

Science (New York, N.Y.)
|February 12, 2026
PubMed
Summary
This summary is machine-generated.

Neuronal activity worsens myelin damage shortly after injury. This finding highlights the detrimental impact of neural function on the central nervous system

More Related Videos

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
12:41

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

4.9K
A Novel Arthroscopic Medial Knot-Tying Suture-Bridge Repair with Rip-Stop Technique for Rotator Cuff Tears
06:41

A Novel Arthroscopic Medial Knot-Tying Suture-Bridge Repair with Rip-Stop Technique for Rotator Cuff Tears

Published on: January 13, 2026

182

Related Experiment Videos

Last Updated: Feb 14, 2026

Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography
06:40

Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography

Published on: June 15, 2018

10.7K
Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
12:41

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

4.9K
A Novel Arthroscopic Medial Knot-Tying Suture-Bridge Repair with Rip-Stop Technique for Rotator Cuff Tears
06:41

A Novel Arthroscopic Medial Knot-Tying Suture-Bridge Repair with Rip-Stop Technique for Rotator Cuff Tears

Published on: January 13, 2026

182

Area of Science:

  • Neuroscience
  • Neurobiology
  • Pathology

Background:

  • Myelin damage is a key feature of neurological injuries.
  • Understanding factors that influence myelin integrity is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the role of neuronal activity in exacerbating myelin damage in the acute phase post-injury.

Main Methods:

  • Utilized in vivo models to assess myelin integrity.
  • Measured neuronal activity levels in conjunction with myelin damage markers.

Main Results:

  • Demonstrated a positive correlation between heightened neuronal activity and increased myelin damage.
  • Observed that active neurons contribute to myelin sheath deterioration.

Conclusions:

  • Neuronal activity is not protective but rather detrimental to myelin in the acute injury period.
  • Targeting neuronal activity may represent a therapeutic strategy to mitigate secondary myelin loss.