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Updated: May 26, 2026
A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants
Published on: February 19, 2016
Molecularly imprinted "on-off" ratiometric fluorescence paper-based sensor for rapid and visual detection of
Mengyu Su1, Zheng Liu1, Long Jing1
1College of Chemical and Biological Enginering, Guilin University of Technology, Guangxi Key Laboratory of Electrochemical and Magneto chemical Functional Materials, Guilin, Guangxi 541004, China.
Abstract:
The overuse of sulfonamide drugs has led to serious ecological problems. A "on-off" ratiometric fluorescence paper-based sensor was developed based on molecularly imprinted polymers (MIPs).This sensor integrates the high specificity of the MIP with the high sensitivity and visual detection capabilities of ratiometric fluorescence and has significant advantages in terms of detection limit and anti-interference ability for the detection of sulfamethoxazole (SMZ) residues in animal-derived foods. A visual detection system was established by coupling the sensor with a smartphone. The results showed that a linear relationship was observed between the SMZ concentration in the range of 0.01-20.00 μM and the fluorescence intensity ratio (F630/F550) (R2 = 0.9970). The detection limit was determined to be 67.9 nM. The spiked recovery rates ranged from 94.30% to 101.06%, with a relative standard deviation of less than 3.02%. The developed method has the advantages of simple operation and low cost, providing a feasible solution for the rapid detection of sulfonamide drug residues and having a promising practical application prospect.
