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Whole-body PET/MRI of Pediatric Patients: The Details That Matter
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Reduced synaptic density in patients with progressive supranuclear palsy: An 18F-SynVest-1 PET study
Xiaoli Hao1, Yulai Li2, Yafei Wen1
1Department of Neurology, Xiangya Hospital Central South University, Changsha, China.
Parkinsonism & Related Disorders
|February 12, 2026
Summary
18F-SynVest-1 PET imaging reveals reduced synaptic density in progressive supranuclear palsy (PSP) patients. This novel PET tracer shows promise for early PSP detection and monitoring disease severity.
Area of Science:
- Neuroscience
- Radiology
- Medical Imaging
Background:
- Progressive supranuclear palsy (PSP) is a neurodegenerative disease marked by early synaptic loss.
- Synaptic vesicle glycoprotein 2A (SV2A) is a key marker for synaptic density.
Purpose of the Study:
- To assess synaptic density in PSP patients using 18F-SynVest-1 positron emission tomography (PET).
- To evaluate the diagnostic efficacy of 18F-SynVest-1 PET for PSP detection.
Main Methods:
- 13 PSP patients and 11 healthy controls underwent 18F-SynVest-1 PET and MRI scans.
- Voxel-based and ROI-based analyses compared synaptic density.
- Receiver operating curve (ROC) analysis assessed diagnostic accuracy.
Main Results:
- PSP patients showed significantly lower synaptic density in the midbrain, basal ganglia, thalamus, and frontal lobes (p < 0.05).
- Left caudate synaptic density distinguished PSP patients from controls with an AUC of 0.94.
- Synaptic density correlated positively with the midbrain to pons ratio in PSP patients (R=0.58, p=0.04).
Conclusions:
- 18F-SynVest-1 PET successfully visualized in vivo synaptic density changes in PSP patients for the first time.
- 18F-SynVest-1 PET demonstrates potential for early PSP detection.
- This PET tracer may aid in monitoring PSP disease severity.
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