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Psychedelics in functional disorders: A scoping review.

Chiranth Bhagavan1, Olivia Carter2, Alexander Bryson3

  • 1Department of Psychiatry, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia; Mental Health Division, Austin Health, Heidelberg, Victoria 3084, Australia; Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, 22-30 Park Avenue, Grafton, Auckland 1023, New Zealand..

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This summary is machine-generated.

Psychedelics show promise for treating functional disorders, with studies indicating symptom improvement. However, more rigorous research is needed to confirm efficacy and safety for these complex conditions.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Functional disorders present significant challenges due to unexplained symptoms and limited treatment options.
  • Psychedelics are emerging as potential therapeutics for various neuropsychiatric conditions.

Purpose of the Study:

  • To conduct a scoping review of studies investigating classic psychedelics for functional disorders.
  • To identify existing knowledge, research gaps, and guide future investigations.

Main Methods:

  • Searched four major databases and clinical trial registries.
  • Included citation searching and relevant website reviews.
  • Analyzed 62 reports from 55 unique studies (surveys, case studies, clinical trials, registered trials).

Main Results:

  • Functional neurological symptoms were the most studied category, with 60.7% showing improvement.
  • Older studies (pre-1976) predominantly used LSD and lacked control groups.
  • Newer registered trials utilize psilocybin and include control groups.

Conclusions:

  • Psychedelics demonstrate potential for treating functional disorders, particularly functional neurological symptoms.
  • Current evidence is limited by study design and methodology.
  • Future research requires standardized protocols, mechanistic studies, and comprehensive safety assessments.