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Updated: Feb 14, 2026
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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Cardiovascular Magnetic Resonance-based Tissue Characteristics and Clinical Outcomes in Apical Hypertrophic
Nili Schamroth Pravda1, Edward Itelman2, Ygal Plakht3
1Department of Cardiology, Tel-Aviv Medical Center, Tel-Aviv, Israel; Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
The American Journal of Cardiology
|February 12, 2026
Summary
Cardiovascular magnetic resonance (CMR) tissue biomarkers like T1, T2, and extracellular volume (ECV) are elevated in apical hypertrophic cardiomyopathy (ApHCM). Increased T2 values and late gadolinium enhancement (LGE) correlate with adverse clinical outcomes in ApHCM patients.
Area of Science:
- Cardiology
- Medical Imaging
- Biomarkers
Background:
- Apical hypertrophic cardiomyopathy (ApHCM) is a distinct phenotype of hypertrophic cardiomyopathy.
- Cardiovascular magnetic resonance (CMR) offers advanced tissue characterization capabilities.
- Understanding tissue biomarkers in ApHCM is crucial for risk stratification.
Purpose of the Study:
- To characterize CMR tissue biomarkers in ApHCM patients.
- To assess the association of these biomarkers with clinical outcomes.
- To evaluate T1, T2, and extracellular volume (ECV) in ApHCM, with and without late gadolinium enhancement (LGE).
Main Methods:
- Comparison of CMR-derived T1, T2, ECV, and LGE between ApHCM patients and controls.
- Assessment of a composite clinical outcome in ApHCM patients.
- Statistical analysis including adjusted odds ratios (AdjOR) for outcome prediction.
Main Results:
- ApHCM patients exhibited higher apical T1, T2, and ECV values compared to controls.
- Elevated T1, T2, and ECV were prevalent even in ApHCM patients without LGE.
- Increased T2 values and LGE were significantly associated with adverse clinical outcomes.
Conclusions:
- CMR tissue biomarkers (T1, T2, ECV) are elevated in the apical segments of ApHCM patients.
- These biomarkers, particularly T2 and LGE, show significant association with clinical outcomes.
- CMR-derived tissue characterization holds potential for risk stratification in ApHCM.
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