Related Experiment Video

Updated: Feb 14, 2026

Author Spotlight: Dissection and Isolation of Region-Specific Decellularized Lung Tissue
05:25

Author Spotlight: Dissection and Isolation of Region-Specific Decellularized Lung Tissue

Published on: September 29, 2023

6.2K

FGFR-driven lung cancer: Dissecting resistance and exploring therapeutic avenues

Pengfei Zhang1, Wuxuan Mei2, Yueru Yao3

  • 1Department of Medical Laboratory, Shenzhen Longhua District Central Hospital, the Affiliated Longhua Hospital of Shenzhen University, Shenzhen 518110, China.

Critical Reviews in Oncology/Hematology
|February 12, 2026
PubMed

Insights

Fibroblast growth factor receptor (FGFR) inhibitors show promise in lung cancer, but resistance limits their effectiveness. This review explores FGFR biology, resistance mechanisms, and strategies to overcome treatment challenges in precision oncology.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Fibroblast growth factor receptors (FGFRs) are key drivers in lung cancer development.
  • Targeting FGFRs represents a significant advance in precision oncology for lung cancer treatment.

Purpose of the Study:

  • To review FGFR biology, genomic alterations, and signaling in lung cancer.
  • To discuss current FGFR inhibitors and their clinical activity.
  • To summarize resistance mechanisms and novel strategies to overcome them.

Main Methods:

  • Literature review of FGFR biology, tumorigenesis, and therapeutic strategies.
  • Analysis of resistance mechanisms including secondary mutations and pathway alterations.
  • Exploration of emerging therapeutic approaches and combination strategies.

Main Results:

  • FGFR alterations are common in lung cancer, with inhibitors showing clinical activity.
  • Diverse resistance mechanisms, including secondary mutations and TME remodeling, limit efficacy.
  • Second-generation inhibitors, mAbs, FGF traps, ADCs, and combination therapies are emerging strategies.

Conclusions:

  • Understanding FGFR biology and resistance is crucial for effective lung cancer treatment.
  • Novel therapeutic strategies are needed to overcome resistance to FGFR-directed therapies.
  • Combination approaches hold promise for enhancing treatment outcomes in FGFR-altered lung cancer.
Keywords:
FGFRInhibitorLung cancerResistanceTreatment

More Related Videos

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer11:31

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

Published on: May 20, 2016

11.3K
In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer07:46

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

Published on: August 17, 2010

34.6K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.1K
Therapeutic Index01:13

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.9K
ATP Driven Pumps I: An Overview01:27

ATP Driven Pumps I: An Overview

ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
10.0K