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Gender equity in pediatric surgical care in Central and South Asia: A systematic review and meta-analysis
Dunya Moghul1, Nadia Babaa2, Sacha Williams1
1McGill University Faculty of Medicine and Health Sciences Quebec, Canada; Harvey E. Beardmore Division of Pediatric Surgery, The Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada.
Insights
Boys show a significant predominance in pediatric surgical care across Central and South Asia (CSA). This finding highlights a potential healthcare inequity in pediatric surgery access that requires further investigation and action.
Area of Science:
- Pediatric Surgery
- Global Health Equity
- Surgical Access Disparities
Background:
- Access to pediatric surgical care in Central and South Asia (CSA) may exhibit gender-based disparities.
- Understanding these disparities is crucial for improving healthcare outcomes for children in the region.
Purpose of the Study:
- To assess gender-based access to pediatric surgical care in Central and South Asia (CSA).
- To compare the sex distribution of pediatric surgical conditions in CSA with that of high-income countries.
Main Methods:
- A systematic review and meta-analysis adhering to PRISMA guidelines.
- Inclusion of 99 pediatric surgical studies from CSA (2004-2023) encompassing 10,508 children and 19 conditions.
- Adjustment for sex-based incidence differences and comparison of sex distributions with high-income country data.
Main Results:
- Boys were significantly overrepresented in acquired conditions (e.g., appendicitis, intussusception) and congenital conditions (e.g., anorectal malformations, esophageal atresia) compared to high-income countries.
- While tumors also showed higher male predominance, the overall difference was not statistically significant.
- Adjusting for the regional sex ratio at birth minimally impacted the observed odds ratios.
Conclusions:
- A significant predominance of boys receiving pediatric surgical care in CSA was identified.
- This observed pattern suggests a potential healthcare inequity in pediatric surgical access.
- Further investigation and targeted interventions are warranted to address this disparity.
Objective:
We assessed gender based access to pediatric surgical care in Central and South Asia (CSA) by reviewing published clinical studies.
Methods:
A PRISMA-guided systematic review and meta-analysis of 99 pediatric surgical studies from CSA (2004-2023) included 10,508 children. Nineteen conditions grouped as acquired, congenital, or tumor related. After adjusting for minor sex based incidence differences using global and regional rates, we compared adjusted sex distributions with those in high-income countries.
Results:
Boys were overrepresented in acquired conditions compared with high-income country M:F ratios, including appendicitis (2:1 vs 1.4:1, p < 0.001) and intussusception (1.9:1 vs 1.5:1, p < 0.001). Congenital conditions showed similar excess boys' predominance: anorectal malformations (1.6:1 vs 1.3:1, p < 0.05), Hirschsprung disease (4.6:1 vs 4:1, p > 0.05), congenital diaphragmatic hernia (2.6:1 vs 1.5:1, p < 0.001), esophageal atresia (3.6:1 vs 1.3:1, p < 0.001), and biliary atresia (2.2:1 vs 0.6:1, p < 0.001). Tumors also showed higher boys' predominance; neuroblastoma (1.8:1 vs 1.2:1, p < 0.05), Wilms' tumor (1.4:1 vs 0.9:1, p < 0.001), and hepatoblastoma (1.6:1 vs 1.2:1, p > 0.05). Meta-analysis confirmed strongest boys' predominance in acquired conditions (n = 3465; log OR 0.75, 95 % CI 0.66-0.84), followed by congenital (n = 2780; log OR 0.43, 95 % CI 0.35-0.50). Tumors showed no significant overall difference (n = 1234; log OR 0.10, p = 0.13). Adjusting for regional sex ratio at birth reduced odds ratios by only 5-6%.
Conclusion:
A significant boys' predominance in pediatric surgical care in CSA was identified. This potential healthcare inequity warrants further investigation and action.
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