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Updated: Feb 14, 2026
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An Enrichment Method for Small Extracellular Vesicles Derived from Liver Cancer Tissue
Published on: February 3, 2023
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Extracellular Vesicles Drive Coagulopathy Across Hematologic Cancers
Charlotte Gran1,2, Sanna Norén3,4, Jovan P Antovic1,2
1Department of Molecular Medicine and Surgery, Coagulation Research, Karolinska Institutet, Stockholm, Sweden.
Seminars in Thrombosis and Hemostasis
|February 12, 2026
Summary
Extracellular vesicles (EVs) play a crucial role in blood clotting for hematological malignancies. Standardizing EV measurement is key for their use as diagnostic biomarkers in these conditions.
Area of Science:
- Hematology
- Oncology
- Biochemistry
Background:
- Coagulopathies are frequent complications in hematological malignancies, leading to severe bleeding or thrombosis.
- Extracellular vesicles (EVs) carry procoagulant and fibrinolytic factors, influencing hemostasis.
- Elevated EV levels and activity are observed at diagnosis in various hematological cancers.
Purpose of the Study:
- To review the role of extracellular vesicles (EVs) in hemostasis within hematological malignancies.
- To discuss current methods for assessing procoagulant EVs.
- To highlight challenges in EV research and clinical translation.
Main Methods:
- Review of clinical and experimental data on EVs in hematological malignancies.
- Assessment of procoagulant EVs using functional assays (TF/PS-dependent), global hemostasis tests, and flow cytometry.
- Analysis of EV-associated coagulation and fibrinolysis in leukemias, plasma cell disorders, and myeloproliferative neoplasms.
Main Results:
- EVs express tissue factor (TF) and phosphatidylserine (PS), initiating coagulation.
- EV procoagulant activity in acute leukemias decreases with treatment but may persist.
- Increased platelet-derived and TF/PS-positive EVs are linked to thrombin generation in plasma cell disorders and myeloproliferative neoplasms.
Conclusions:
- EVs are implicated in hemostasis across diverse hematological malignancies.
- Methodological heterogeneity hinders comparability and clinical application of EV research.
- Standardized protocols and robust clinical studies are necessary to validate EVs as biomarkers.
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