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Updated: Feb 14, 2026

Demonstration of the Rat Ischemic Skin Wound Model
Published on: April 1, 2015
Light-driven switchable polyacrylamide/chitosan-based hydrogel dressings for outdoor wound temperature regulation and
Tianyi Lu1, Qianqian Wang2, Meng Sun1
1Jiangsu Key Laboratory for Design and Manufacturing of Precision Medicine Equipment, School of Mechanical Engineering, Southeast University, Nanjing, Jiangsu, 211189, China.
Abstract:
Proper temperature management has been acknowledged for wound repair, but skin wounds exposed to the outdoors are inevitably susceptible to intense solar radiation and extreme temperatures. However, the wound thermal environment is easily disrupted even treated by the functional dressings with limited thermal adaptability, gradually hindering the process of wound healing. Herein, we propose an outdoor light-driven dual thermal management system sequentially employing cooling and heating dressings to optimize the temperature of wounds and accelerate wound healing. The cooling dressing integrates a light porous poly(vinyl alcohol)/SiO2 aerogel exhibiting high solar reflectance (≈91.5%) and strong mid-infrared emissivity (≈95.6%) with a self-adhesive, antibacterial polyacrylamide/chitosan hydrogel. It achieves substantial coupled radiative and evaporative cooling in the outdoors, lowering the rat wound temperature by approximately 6 °C under direct sunlight. Conversely, the heating dressing of polyacrylamide/chitosan/CNT-COOH hydrogel can rapidly reach ≈45 °C under near-infrared irradiation (808 nm, 0.5 W cm-2), providing mild photothermal antibacterial effects. Critically, the sequential application of cooling and heating dressings in a wound model of SD rats notably enhanced skin regeneration. This work develops a low-cost, energy-efficient approach for outdoor wound thermal environment regulation, inspiring the design of personalized healthcare devices under detrimental environmental conditions.
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