Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

4.4K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.4K
Relationship Formation02:12

Relationship Formation

46.3K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
46.3K
Telomeres and Telomerase02:41

Telomeres and Telomerase

27.4K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
27.4K
The Sense of Self: Reflected Self-Appraisal and Social Comparison02:57

The Sense of Self: Reflected Self-Appraisal and Social Comparison

56.2K
According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.2K
Stereotype Content Model02:16

Stereotype Content Model

15.5K
The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
15.5K
Framing Effects03:26

Framing Effects

8.0K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How to measure and model cardiovascular aging.

Cardiovascular research·2025
Same author

Cardiovascular inflammaging: Mechanisms, consequences, and therapeutic perspectives.

Cell reports. Medicine·2025
Same author

Notch activity is modulated by the aGPCR Latrophilin binding the DSL ligand in C. elegans.

Nature communications·2025
Same author

Roadmap for alleviating the manifestations of ageing in the cardiovascular system.

Nature reviews. Cardiology·2025
Same author

Beyond incretins: targeting neurokinin receptors for obesity treatment.

Signal transduction and targeted therapy·2025
Same author

The Adhesion GPCR ADGRL2/LPHN2 Can Protect Against Cellular and Organismal Dysfunction.

Cells·2024

Related Experiment Video

Updated: Feb 14, 2026

Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry
14:01

Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry

Published on: September 13, 2022

5.8K

Old Friends, New Faces in Endothelial Dysfunction and Senescence.

Niloofar Ale-Agha1, Philipp Jakobs1,2, Anne Rafflenbeul1

  • 1Haendeler Group, Cardiovascular Degeneration, Central Institute of Clinical Chemistry and Laboratory Medicine, Medical Faculty, University Hospital and Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.

Antioxidants & Redox Signaling
|February 12, 2026
PubMed
Summary

Cardiovascular diseases are linked to aging, causing endothelial dysfunction. New research identifies proteins involved in aging vascular dysfunction, offering potential therapeutic targets for these age-related conditions.

Keywords:
CDKN1B/p27KIP1ER selenoproteinsGPCRsTERTendothelial cell senescencevascular aging

More Related Videos

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

35.2K
A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

21.3K

Related Experiment Videos

Last Updated: Feb 14, 2026

Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry
14:01

Far-Red Fluorescent Senescence-Associated β-Galactosidase Probe for Identification and Enrichment of Senescent Tumor Cells by Flow Cytometry

Published on: September 13, 2022

5.8K
Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

35.2K
A Sensitive Method to Quantify Senescent Cancer Cells
09:18

A Sensitive Method to Quantify Senescent Cancer Cells

Published on: August 2, 2013

21.3K

Area of Science:

  • Vascular Biology
  • Aging Research
  • Cardiovascular Disease

Background:

  • Aging impairs endothelial cell function through disrupted redox and proteostasis, and mitochondrial dysfunction.
  • Several proteins, including G protein-coupled receptors and specific inhibitors like cyclin-dependent kinase inhibitor 1B/p27KIP1, have newly identified roles in aging endothelium.
  • These proteins, some with novel mitochondrial functions, are critical for maintaining vascular health during aging.

Purpose of the Study:

  • To review recent advances in understanding molecular mechanisms underlying aging-associated endothelial dysfunction.
  • To identify potential therapeutic targets for cardiovascular diseases linked to the aging process.
  • To highlight proteins with newly discovered roles in vascular maintenance and senescence.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of proteins involved in cellular homeostasis and mitochondrial function in the context of aging.
  • Evaluation of potential therapeutic strategies targeting identified molecular pathways.

Main Results:

  • Proteins previously known for other functions are now implicated in regulating endothelial senescence and aging.
  • Specific proteins, including cyclin-dependent kinase inhibitor 1B/p27KIP1 and telomerase reverse transcriptase, exhibit critical roles in mitochondria.
  • These findings suggest novel therapeutic avenues for age-related vascular diseases.

Conclusions:

  • Several newly identified pathways and proteins are relevant for endothelial function in aging.
  • Further research is essential to elucidate the precise molecular mechanisms and therapeutic potential.
  • Critical investigation of potential side effects is necessary before targeting these proteins therapeutically.