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OnCorr: A pan-cancer mRNA-protein correlation tool for precision oncology
Urwah Nawaz1,2, Niantao Deng1, Ori Livson1
1ProCan®, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia.
None:
Proteins are ultimately responsible for cellular phenotypes and are targeted by most anticancer drugs. However, beyond immunohistochemistry, proteins are not typically measured in precision oncology, meaning transcriptomics is used as a proxy. To determine how informative mRNA is for guiding personalised treatments, mRNA-protein correlations were analysed in three large pan-cancer datasets and made available in a web portal ( https://oncorr.aws.procan.org.au/ ). OnCorr can be integrated into precision medicine programs to augment transcriptomics.
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