Related Experiment Video
Updated: Feb 14, 2026
Visual Evoked Potential Recordings in Mice Using a Dry Non-invasive Multi-channel Scalp EEG Sensor
Published on: January 12, 2018
Metabolomics in Scalp Seborrheic Dermatitis Evidenced Key Changes in Inflammatory Markers Following a 10-Week Scalp
Camille Géniès1, Martine Maître2, Sophie Baradat2
1Pierre Fabre Dermo-Cosmetic and Personal Care, Research & Development, 3 Avenue Hubert Curien, BP 13562, 31100, Toulouse, France. camille.genies@pierre-fabre.com.
Introduction:
Mild-to-moderate scalp seborrheic dermatitis (SD) is commonly managed by using anti-SD shampoos containing antifungal, anti-inflammatory, and keratolytic agents. A newly formulated anti-SD shampoo containing the patented combination of two antifungal actives has shown good clinical efficacy and tolerability in a previous two-phase randomized controlled trial.
Methods:
A specific analysis of scalp SD-associated metabolome was conducted to identify molecular markers involved in SD symptoms, and examine the impact of the anti-SD shampoo on these compounds. The intervention scheme involved a 2-week phase of intensive product use (three times a week), followed by an 8-week parallel-group maintenance phase consisting of the test group using the study shampoo once a week, and the control group using a neutral shampoo.
Results:
Following the intensive phase of the intervention, a significant decrease in the levels of SD markers (cathepsin S, interleukin-8, and histamine), inflammatory lipids (arachidonic acid, linoleic acid, and oxylipins), and metabolites involved in tryptophan metabolism (indolacetate and indolelactate) was observed. These changes were sustained during the maintenance phase in the test group only, supporting the clinical efficacy of the anti-SD shampoo. The integrated analysis of metabolome and fungal microbiome data suggested a positive correlation between the level of Malassezia fungi and that of two oxylipins (9,10,13-triHOME and 9-HODE), highlighting the pivotal role of these lipolytic fungi in SD conditions, and the involvement of newly identified proinflammatory lipid mediators. These oxylipins could be used as novel targets for developing alternative anti-SD strategies.
Conclusion:
This approach allowed us to better characterize specific interactions within the scalp ecosystem providing deeper insights and unravelling new therapeutic pathways in SD like pro-inflammatory oxylipins.
Gov Identifier:
NCT06578962 (retrospectively registered on August 28, 2024).
More Related Videos
10:27Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
11:25Simultaneous Scalp Electroencephalography EEG, Electromyography EMG, and Whole-body Segmental Inertial Recording for Multi-modal Neural Decoding
Published on: July 26, 2013
Related Concept Videos
01:34The Z-Scheme of Electron Transport in Photosynthesis
01:19Key Techniques in Microbiology
02:35Key Elements for Plant Nutrition
01:28Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
01:24Inflammatory Response II: Inflammatory Exudate and Tissue Repair
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
01:21Interdisciplinary Care: The Health Care Team-I
Physicians
The physician's primary responsibility is to diagnose illness and direct the medical or surgical treatment of the condition. The authority to admit patients to a healthcare agency or institution and practice care within that setting is granted to physicians by the healthcare agency or institution...