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Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids01:31

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In the complex environment of the gastric lumen, excessive acid secretion can lead to the formation or worsening of ulcers within the delicate mucosal layer. Antacids, such as sodium bicarbonate and calcium carbonate, provide relief by neutralizing this acid, transforming it into harmless salt and water. This neutralization process raises the gastric pH from a highly acidic level of 1 to a more basic 3-4, reducing the acidity within the stomach.
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Drug Delivery: Enteral Route01:18

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Hydrogel-enabled drug delivery for ulcerative colitis.

Mohit Sharma1, Rupa Mazumder2, Abhijit Debnath1

  • 1Department of Pharmaceutics, Noida Institute of Engineering and Technology (Pharmacy Institute), Knowledge Park-II, Greater Noida, Uttar Pradesh, 201306, India.

Inflammopharmacology
|February 12, 2026
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Summary
This summary is machine-generated.

Hydrogel drug delivery systems offer advanced solutions for ulcerative colitis (UC) by enabling targeted delivery and controlled release of therapeutics. These innovative platforms show promise for improving treatment efficacy and patient outcomes in managing this chronic inflammatory condition.

Keywords:
Colon-targeted therapyHydrogel drug deliveryInflammatory bowel diseaseMucoadhesive systemsStimuli-responsive systemsUlcerative colitis

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Gastroenterology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited treatment options.
  • Conventional therapies for UC face challenges like poor drug accumulation and systemic toxicity.
  • Hydrogel drug delivery systems present a promising alternative for UC management.

Purpose of the Study:

  • To review the current state and future potential of hydrogel-based drug delivery for ulcerative colitis.
  • To explore material design, stimuli-responsive mechanisms, targeting strategies, and therapeutic cargo for UC treatment.
  • To discuss challenges and future perspectives for clinical translation.

Main Methods:

  • Review of natural, synthetic, and hybrid hydrogel systems for UC therapy.
  • Analysis of stimuli-responsive mechanisms (pH, enzyme, redox) for targeted drug release.
  • Examination of advanced targeting strategies (mucoadhesive, cell-specific) and therapeutic cargo (biologics, nanomedicines).

Main Results:

  • Hydrogels offer tunable properties for controlled release and enhanced colonic accumulation.
  • Stimuli-responsive and targeted hydrogels achieve site-specific drug delivery in inflamed colons.
  • Novel hydrogel formulations show superior efficacy in preclinical UC models.

Conclusions:

  • Hydrogel-based drug delivery systems hold significant potential for transforming UC treatment.
  • Future research should focus on smart hydrogels, combination therapies, and personalized medicine approaches.
  • Integration of materials science, biotechnology, and digital health will advance IBD management.