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Updated: Feb 14, 2026

Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
Pharmacologic management of renal involvement in monogenic autoinflammatory diseases
Ahmed Fayed1, Mohamed Tharwat Hegazy2, Jurgen Sota3
1Nephrology Unit, Internal Medicine Department, Cairo University, Cairo, Egypt.
Abstract:
Kidney involvement represents one of the main targets of the systemic inflammatory process and is underscored by a heterogeneous pathology ranging from amyloidosis to non-amyloid-related damage rooted in inflammasome activation. A thorough approach to monogenic autoinflammatory disorders (AIDs) includes identifying phenotypic patterns, comprehending pathophysiology, and customizing therapy to improve patients' quality of life. In this review, we will discuss some pharmacological aspects focusing on the kidney as a target in AIDs. A special emphasis will be placed on medications used for AIDs cases with renal impairment, as well as drug-induced nephrotoxicity in monogenic AIDs. Understanding the mechanisms of drug-induced nephrotoxicity and applying preventive measures are critical for safely managing monogenic AIDs with renal involvement.
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