Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Balancing Redox Equations02:58

Balancing Redox Equations

62.5K
Electrochemistry is the science involved in the interconversion of electrical and chemical reactions. Such reactions are called reduction-oxidation, or redox reactions. These important reactions are defined by changes in oxidation states for one or more reactant elements and include a subset of reactions involving the transfer of electrons between reactant species. Electrochemistry as a field has evolved to yield sufficient insights on the fundamental principles of redox chemistry and multiple...
62.5K
Equilibrium and Balance01:15

Equilibrium and Balance

6.7K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
6.7K
Energy Balance01:19

Energy Balance

1.3K
The human body gets energy from the three macronutrients: carbohydrates, proteins, and fats. Energy is released when the chemical bonds in the organic compounds present in the food are broken down. The energy content of food is measured in kilocalories (kcal), defined as the amount of heat required to raise the temperature of one kilogram of water by one degree Celsius. This value is determined by measuring the temperature change of the water surrounding a calorimeter after the complete...
1.3K
Respiratory Regulation of Acid-Base Balance01:18

Respiratory Regulation of Acid-Base Balance

1.8K
Respiratory compensation is a vital physiological process that stabilizes blood plasma pH by regulating the partial pressure of carbon dioxide (PCO2), a key determinant of pH levels. Most carbon dioxide in the blood dissolves and converts into carbonic acid (H2CO3). It dissociates into hydrogen ions (H+) and bicarbonate ions (HCO3⁻). There is also an inverse relationship between PCO2​​ and pH.
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
1.8K
Disorder of Water Balance01:29

Disorder of Water Balance

2.6K
Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
2.6K
Acid-Base Balance01:25

Acid-Base Balance

2.8K
The human body maintains a narrow pH range regulated through acid-base balance. This balance is crucial as changes in the hydrogen ion concentration can disrupt cell membrane stability, alter protein structures, and change enzyme activities. The normal pH of arterial blood is 7.4, venous blood and interstitial fluid is 7.35, and intracellular fluid averages 7.0.
When the pH of arterial blood rises above 7.45, it results in a condition called alkalosis. Conversely, a drop below 7.35 leads to...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Platelet mTOR Is a Regulator of Sterile Immunothrombosis.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Neutralizing Histones Improves Endogenous Fibrinolysis in Stroke.

Arteriosclerosis, thrombosis, and vascular biology·2025
Same author

Mitochondrial Calcium Uniporter Regulates ITAM-Dependent Platelet Activation.

Circulation research·2025
Same author

Aging platelets shift their hemostatic properties to inflammatory functions.

Blood·2025
Same author

Mitofusin-2 Regulates Platelet Mitochondria and Function.

Circulation research·2023
Same author

Investigation of Neutrophil Extracellular Traps as Potential Mediators in the Pathogenesis of Non-Acute Subdural Hematomas: A Pilot Study.

Diagnostics (Basel, Switzerland)·2022
Same journal

EXPRESS: Therapeutic Hypothermia Via Hypothalamic Neuromodulation: A New Approach for Stroke Brain Protection.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Endothelial estrogen receptor alpha (ESR1) regulates cerebral cavernous malformation pathogenesis via MEKK3-KLF signalling pathway.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: The Role and Mechanism of Lysyl Hydroxylase 1 (LH1) in Vascular Lesions in Hypertensive Intracerebral Hemorrhage.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

Brain barriers as checkpoints in endocrine regulation of body homeostasis.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

Ferroptosis of microvascular pericytes contributes to ischemia-reperfusion injury in mice.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same journal

EXPRESS: Post-Ischemic Sodium Glucose Cotransporter Inhibition Attenuates Ischemia-Reperfusion Injury via Regulation of Mitochondrial Membrane Potential.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
See all related articles

Related Experiment Video

Updated: Feb 14, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.7K

Targeting platelets in ischemic stroke: Balancing on a tightrope.

Frederik Denorme1

  • 1Laboratory of Cell Biology and Histology, Faculty of Biomedical, Pharmaceutical and Veterinary sciences, University of Antwerp, Wilrijk, Belgium.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|February 13, 2026
PubMed
Summary
This summary is machine-generated.

Platelets play a dual role in ischemic stroke, contributing to clot formation and inflammation, yet also offering neuroprotection. Selective modulation of platelet pathways, not broad inhibition, may improve outcomes.

Keywords:
Plateletsischemic strokeneutrophilsreperfusion injurythrombo-inflammation

More Related Videos

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

1.6K
A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation
11:06

A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation

Published on: April 12, 2016

10.9K

Related Experiment Videos

Last Updated: Feb 14, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.7K
Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
11:32

Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke

Published on: January 3, 2025

1.6K
A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation
11:06

A Human-machine-interface Integrating Low-cost Sensors with a Neuromuscular Electrical Stimulation System for Post-stroke Balance Rehabilitation

Published on: April 12, 2016

10.9K

Area of Science:

  • Neuroscience
  • Hematology
  • Immunology

Background:

  • Platelets are traditionally known for hemostasis and thrombosis.
  • Emerging evidence highlights their roles in inflammation and neural repair.
  • In ischemic stroke, platelets contribute to thrombus formation and microvascular dysfunction.

Purpose of the Study:

  • To explore the complex roles of platelets in ischemic stroke.
  • To investigate the potential for targeted antiplatelet therapies.

Main Methods:

  • Review of preclinical and translational research.
  • Analysis of platelet interactions with leukocytes and endothelial cells.
  • Exploration of platelet phenotyping and pharmacogenomics.

Main Results:

  • Platelets amplify thrombotic and inflammatory pathways, worsening ischemic injury.
  • Platelets paradoxically protect the brain by maintaining vascular stability.
  • Selective modulation of platelet-immune pathways shows promise for enhanced reperfusion and neuroprotection.
  • Broad platelet inhibition is not advised in acute ischemic stroke.

Conclusions:

  • Platelets are critical modulators of ischemic brain injury and repair.
  • Precision antiplatelet strategies tailored to individual patient profiles are the future of stroke treatment.
  • Understanding the dual hemostatic and inflammatory functions of platelets is essential for therapeutic advancements.