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Design of Multifunctional SC-PLA Pesticide Carrier System and Study of Controlled-Release Performance
Xuanxuan Wang1, Ruizhe Wang1, Dongxia Han1
1College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
Materials (Basel, Switzerland)
|February 13, 2026
Summary
This study developed avermectin (Avm) nanoformulations using stereocomplex polylactic acid (SC-PLA) for enhanced delivery. The novel SC-PLA carrier system offers controlled release, stability, and environmental responsiveness for pesticide and pharmaceutical applications.
Area of Science:
- Polymer Science
- Materials Science
- Nanotechnology
Background:
- Developing effective drug delivery systems is crucial for improving pesticide and pharmaceutical efficacy.
- Avermectin (Avm) requires advanced carriers for stable encapsulation and controlled release.
- Stereocomplex (SC) crystal formation offers unique properties for polymer-based nanoformulations.
Purpose of the Study:
- To create a high-performance avermectin (Avm) carrier system using stereocomplex polylactic acid (SC-PLA).
- To investigate the properties and performance of Avm-loaded SC-PLA nanoformulations.
- To evaluate the potential of this novel carrier in pesticide and pharmaceutical applications.
Main Methods:
- Utilized stereocomplex (SC) crystal formation between poly (L-lactic acid) (PLLA) and poly (D-lactic acid) (PDLA).
- Prepared Avm-loaded SC-PLA nanoformulations via the emulsion solvent evaporation method.
- Characterized the morphology, crystallinity, and drug loading of the nanoformulations.
Main Results:
- Successfully formed SC-PLA, enabling tunable Avm@SC-PLA nanospheres with regular morphology.
- Demonstrated controlled release characteristics and pH-responsive properties (pH 5.5, 7.4, 8.0).
- Highlighted advantages including controllable particle size, efficient drug loading, sustained release, UV-shielding, stability, spreadability, and leaf affinity.
Conclusions:
- The Avm@SC-PLA nanoformulation effectively loads and encapsulates Avm with good structural stability and environmental responsiveness.
- This novel PLA-based carrier strategy facilitates efficient delivery of Avm.
- The nanoformulation shows potential for application in the pesticide and pharmaceutical fields.
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