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Related Experiment Video

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Fast and Accurate Exhaled Breath Ammonia Measurement
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Exhaled Breath Analysis for Head and Neck Cancer Using Fourier-Transform Infrared Spectroscopy: A Feasibility Study

Kota Nakasuji1, Yoshihito Tanaka1, Masato Yamamoto2

  • 1Department of Otorhinolaryngology-Head and Neck, Odawara Municipal Hospital, Kanagawa 250-8558, Japan.

Diagnostics (Basel, Switzerland)
|February 13, 2026
PubMed
Summary
This summary is machine-generated.

Fourier-transform infrared (FTIR) spectroscopy of exhaled breath shows promise for non-invasive head and neck cancer screening. This method offers a feasible alternative to endoscopy for early detection.

Keywords:
FTIRexhaled breathhead and neck cancerscreening

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Area of Science:

  • Biomedical Engineering
  • Spectroscopy
  • Oncology

Background:

  • Early detection of head and neck cancer improves patient outcomes.
  • Current screening methods like endoscopy are invasive and require specialist expertise.
  • A simpler, non-invasive screening tool is needed.

Purpose of the Study:

  • To evaluate the clinical feasibility of Fourier-transform infrared (FTIR) spectroscopy for analyzing exhaled breath as a non-invasive screening tool for head and neck cancer.

Main Methods:

  • Exhaled breath samples from head and neck cancer patients (n=10) and healthy controls (n=14) were analyzed using FTIR spectroscopy.
  • Infrared absorption spectra were compared between groups.
  • Receiver operating characteristic (ROC) analysis was performed.

Main Results:

  • FTIR spectroscopy identified significant differences in breath spectra between patients and controls (2691 wavenumber points, p < 0.05).
  • A specific wavenumber (3917.3 cm⁻¹) showed a strong difference (p = 0.00015).
  • ROC analysis yielded an area under the curve of 0.929, indicating good discriminative performance.

Conclusions:

  • FTIR-based exhaled breath analysis is a non-invasive and feasible method for screening head and neck cancer.
  • The technique shows potential for clinical application in cancer screening.
  • This approach may be adaptable for detecting other diseases.