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Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

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Cutaneous Adverse Effects in Patients Treated with BTK Inhibitors.

Ewa Robak¹, Tadeusz Robak^2,3

¹Department of Dermatology, Medical University of Lodz, 90-647 Łódź, Poland.

|February 13, 2026

Summary

Bruton

Keywords:

BTK inhibitors acalabrutinib bleeding ibrutinib infections mucosal symptoms neutrophilic dermatoses pirtobrutinib rash skin toxicity zanubrutinib

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Area of Science:

Oncology
Dermatology
Pharmacology

Background:

Bruton's tyrosine kinase (BTK) inhibitors are vital for treating indolent lymphoid malignancies like CLL and MCL.
Common adverse events include cardiac issues, infections, and skin changes.
First-generation BTK inhibitors (e.g., ibrutinib) have a higher toxicity profile than newer agents.

Purpose of the Study:

To review the spectrum of skin symptoms associated with BTK inhibitor therapy.
To compare the dermatologic toxicity of ibrutinib with newer BTK inhibitors.
To summarize the clinical and pathological features of BTK inhibitor-induced skin reactions.

Main Methods:

A comprehensive literature search was conducted using PubMed, Web of Science, and Google Scholar.
English-language articles were prioritized.
References from selected articles were reviewed for additional relevant publications.

Main Results:

Skin manifestations are common BTK inhibitor side effects, particularly with ibrutinib.
Hemorrhage, bruising, and contusions are frequent skin toxicities.
Other dermatologic issues include rash, cellulitis, infections, abscesses, and edema.

Conclusions:

BTK inhibitors, while effective, are associated with various skin toxicities.
Second-generation and non-covalent BTK inhibitors appear to have a more favorable dermatologic safety profile than ibrutinib.
Understanding and managing these skin symptoms is crucial for patient care.