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Association of p53 Pro72Arg Polymorphism with Hepatocellular Carcinoma Risk in Hepatitis B Across Multiethnic
Ulfa Kholili1,2, Amal Arifi Hidayat2,3, Ugroseno Yudho Bintoro4
1Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, Indonesia.
Cancers
|February 13, 2026
Summary
The p53 Pro72Arg polymorphism may increase hepatocellular carcinoma risk in Indonesian chronic hepatitis B patients, especially within the Madurese ethnic group and those with decompensated cirrhosis. This genetic variant influences liver cancer development.
Area of Science:
- Genetics
- Hepatology
- Oncology
Background:
- Chronic hepatitis B infection is a major risk factor for hepatocellular carcinoma (HCC).
- The p53 Pro72Arg single-nucleotide polymorphism (SNP) is implicated in hepatocarcinogenesis.
- Limited research exists on this SNP in Indonesia's diverse ethnic populations.
Purpose of the Study:
- To investigate the association between the p53 Pro72Arg polymorphism and HCC risk in Indonesian patients with chronic hepatitis B.
- To explore ethnic-specific associations within Indonesia's diverse genetic landscape.
Main Methods:
- Genotyping of the p53 Pro72Arg polymorphism using direct DNA sequencing.
- Analysis of 140 chronic hepatitis B patients (79 HCC, 61 controls).
Main Results:
- No overall association between p53 Pro72Arg SNPs and HCC risk in the general Indonesian population.
- Increased HCC susceptibility observed in Madurese individuals with Pro/Arg and Arg/Arg genotypes.
- Heterozygote Pro/Arg genotype linked to higher HCC risk in patients with decompensated cirrhosis.
Conclusions:
- The p53 Pro72Arg polymorphism may contribute to liver cancer development in specific Indonesian populations.
- Ethnic background (Madurese) and liver decompensation are key factors influencing the SNP's role in HCC risk.
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