Related Experiment Video

Updated: Feb 14, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy

Published on: April 29, 2014

17.2K

FGFR Testing in Metastatic Urothelial Carcinoma-Who, When, and How to Test

André Mansinho1,2, José Carlos Machado3,4,5, Cátia Faustino6

  • 1START Lisbon, Hospital de Santa Maria, Unidade Local de Saúde Santa Maria, 1649-035 Lisbon, Portugal.

Cancers
|February 13, 2026
PubMed

Insights

Accurate FGFR3 testing is crucial for selecting patients with metastatic urothelial carcinoma (mUC) for targeted therapies like erdafitinib. Standardizing this molecular profiling ensures optimal treatment planning for improved outcomes in mUC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Metastatic urothelial carcinoma (mUC) presents limited treatment options.
  • Genomic research has identified actionable molecular targets in mUC.
  • Fibroblast growth factor receptor 3 (FGFR3) alterations are key drivers in bladder cancer.

Purpose of the Study:

  • To review key considerations for FGFR3 testing in mUC.
  • To discuss the routine incorporation of FGFR3 testing into clinical practice.
  • To highlight the importance of molecular profiling for guiding FGFR inhibitor therapy.

Main Methods:

  • Review of genomic and transcriptomic research in mUC.
  • Analysis of clinical trial data, including the THOR trial.
  • Discussion of molecular profiling techniques and standardization.

Main Results:

  • FGFR3 alterations are predictive biomarkers for FGFR inhibitor response.
  • Erdafitinib demonstrated clinical benefit in previously treated mUC patients with FGFR3 alterations.
  • Accurate and timely FGFR3 testing is essential for patient selection.

Conclusions:

  • FGFR3 testing is critical for optimizing treatment with FGFR inhibitors in mUC.
  • Standardization of FGFR3 testing is needed for clinical practice.
  • Molecular profiling advances have expanded therapeutic options for mUC.
Keywords:
FGFR alterationbiomarkermetastatic urothelial carcinomamolecular testingprecision oncologytargeted therapy

More Related Videos

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis09:28

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis

Published on: May 12, 2019

10.8K
Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

9.5K

Related Concept Videos

Testes: Histology01:27

Testes: Histology

A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
3.1K
Complementation Tests00:49

Complementation Tests

A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.3K
Significance Testing: Overview01:04

Significance Testing: Overview

Significance testing is a set of statistical methods used to test whether a claim about a parameter is valid. In analytical chemistry, significance testing is used primarily to determine whether the difference between two values comes from determinate or random errors. The effect of a particular change in the measurement protocol, analyst, or sample itself can cause a deviation from the expected result. In the case of a suspected deviation/outlier, we need to be able to confirm mathematically...
12.8K
Testes: Gross Anatomy01:19

Testes: Gross Anatomy

The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
6.6K
Testing Water Quality01:14

Testing Water Quality

When the quality of water for concrete preparation is uncertain, its impact on the setting time of cement and compressive strength of mortar is assessed by comparison with de-ionized or distilled water benchmarks. American Society for Testing and Materials (ASTM) C1602 requires the setting times to be within 90 minutes of the control, British Standard (BS) 3146:1980 allows a 30-minute variance in the initial setting, while British Standards European Norm (BS EN) 1008 specifies initial setting...
396
Types of Hypothesis Testing01:11

Types of Hypothesis Testing

There are three types of hypothesis tests: right-tailed, left-tailed, and two-tailed.
When the null and alternative hypotheses are stated, it is observed that the null hypothesis is a neutral statement against which the alternative hypothesis is tested. The alternative hypothesis is a claim that instead has a certain direction. If the null hypothesis claims that p = 0.5, the alternative hypothesis would be an opposing statement to this and can be put either p > 0.5, p < 0.5, or p...
28.1K