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Updated: Feb 14, 2026
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Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
Published on: October 9, 2014
13.4K
Gastric Cancer Epithelial-Mesenchymal Transition-The Role of Micro-RNA
Maciej Biskupski1, Adam Brachet2, Gabriela Hunek1
1Chair and Department of Forensic Medicine, Medical University of Lublin, ul. Jaczewskiego 8b, 20-090 Lublin, Poland.
Cancers
|February 13, 2026
Summary
MicroRNAs (miRNAs) significantly regulate epithelial-mesenchymal transition (EMT) in gastric cancer, influencing invasion and treatment resistance. Restoring tumor-suppressive miRNAs and targeting oncomiRs offers potential therapeutic strategies for gastric cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Epithelial-mesenchymal transition (EMT) is crucial for gastric cancer progression, including invasion, metastasis, and treatment resistance.
- The post-transcriptional regulation of EMT by microRNAs (miRNAs) in gastric cancer is not fully understood.
- Understanding miRNA networks is vital for developing novel therapeutic strategies.
Purpose of the Study:
- To systematically review and synthesize the role of miRNAs in regulating EMT in gastric cancer.
- To delineate tumor-intrinsic, microenvironmental, and circulating EMT-related miRNA networks.
- To identify potential miRNA biomarkers and therapeutic targets for gastric cancer.
Main Methods:
- A structured literature search was conducted across PubMed, Web of Science, and Scopus.
- Studies evaluating miRNAs in relation to EMT in gastric cancer were synthesized.
- EMT-related miRNA networks were analyzed in tumor-intrinsic, microenvironmental, and circulating contexts.
Main Results:
- Downregulated tumor-suppressive miRNAs (e.g., miR-34a, miR-200 family) target EMT pathways, and their restoration reverses EMT phenotypes.
- Upregulated oncomiRs (e.g., miR-21, miR-17-5p) reinforce EMT pathways by targeting tumor suppressors.
- Microenvironmental and circulating miRNAs, along with systemic indices like neutrophil-to-lymphocyte ratio, contribute to EMT regulation.
- EMT-related miRNAs correlate with invasion, metastasis, prognosis, and chemoresistance, with many detectable in circulation.
Conclusions:
- EMT-related miRNAs are key regulators of gastric cancer cell plasticity and tumor-microenvironment interactions.
- These miRNAs represent promising candidates for biomarkers and therapeutics in gastric cancer.
- Further prospective, subtype-stratified, and translational studies are warranted for validation.
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