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Selected Potential Biomarkers in Laryngeal Cell Carcinomas.
Roman Paduch1,2, Maria Klatka3, Janusz Klatka4
1Department of Virology and Immunology, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, 20-033 Lublin, Poland.
Cancers
|February 13, 2026
Summary
Biomarkers can help personalize laryngeal squamous carcinoma treatment. Analyzing genetic, immune, and growth factors aids in staging, assessing aggressiveness, and predicting prognosis for head and neck cancer patients.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Laryngeal squamous carcinoma is a significant head and neck cancer.
- Current treatment selection for this cancer is challenging.
- Biomarker analysis offers a potential solution for personalized treatment.
Purpose of the Study:
- To categorize biomarkers for laryngeal squamous carcinoma.
- To describe various biomarker groups and their molecular pathways.
- To illustrate the potential clinical utility of these biomarkers.
Main Methods:
- Biomarkers were grouped based on molecular pathways or specific molecules.
- Included genetic factors, apoptosis regulators, angiogenesis factors, cell structure regulators, immune factors (e.g., PD-L1), hormone receptors, growth factor pathways, and cell cycle regulators.
- Representative examples were discussed for each group.
Main Results:
- Biomarkers were systematically classified into distinct functional groups.
- Specific examples highlighted the relevance of each biomarker category.
- The potential applications in clinical decision-making were demonstrated.
Conclusions:
- Biomarker analysis provides a structured approach to understanding laryngeal squamous carcinoma.
- These biomarkers show promise for improving cancer staging and prognosis.
- Personalized treatment strategies can be informed by evaluating these molecular factors.
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