Gray Matter Volumetry and Cognitive Functioning in Pediatric Posterior Fossa Tumor Survivors

Background/Objectives: Posterior fossa tumors (PFTs) often require radiotherapy which may damage both cortical and subcortical brain tissue. We examined voxel-based and region-based gray matter volume (GMV) alterations and explored their relation to cognitive functioning. Methods: Using T1-weighted MR imaging, intelligence scores from the Wechsler Adult Intelligence Scale-IV (WAIS-IV), and domain scores for language, learning, and memory, complex attention and cognitive flexibility were investigated in 18 of 21 assessed PFT survivors and 21 matched controls. GMV was quantified with voxel-based and region-based volumetry, compared among groups (controls versus survivors, irradiated versus non-irradiated survivors), and correlated with cognitive performance. Results: Survivors showed reduced GMV in two voxel-based clusters, located in the left occipital fusiform area and the left pallidum. Region-based analyses showed lower GMV in survivors located in subcortical areas, while higher GMV was observed in the left inferior temporal region. Survivors who received craniospinal radiation exhibited reductions in GMV in bilateral thalami, right ventral diencephalon, and central corpus callosum, and higher GMV in the bilateral middle temporal regions. Compared to controls, survivors scored lower for all cognitive domains, except for complex attention and cognitive flexibility. Amongst survivors, the GMV of the bilateral thalami and right ventral diencephalon correlated positively with working memory. Conclusions: Overall, PFT survivors demonstrated both alterations in GMV and cognitive functioning, with the most pronounced GMV deviations found in those treated with craniospinal radiation. Reduced GMV was associated with poorer cognitive performance.