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Related Concept Videos

Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
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ATP-driven pumps, also known as transport ATPases, are integral membrane proteins. They have binding sites for ATP located on the membrane's cytosolic side and the ion-conducting domain in the transmembrane region. These pumps use the free energy released from ATP hydrolysis to move the solutes across cell membranes against an electrochemical gradient.
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Atoms — and the protons, neutrons, and electrons that compose them — are extremely small. For example, a carbon atom weighs less than 2 × 10−23 g. When describing the properties of tiny objects such as atoms, we use appropriately small units of measure, such as the atomic mass unit (amu). The amu was originally defined based on hydrogen, the lightest element, then later in terms of oxygen. Since 1961, it has been defined with regard to the most abundant isotope of carbon, atoms of which...
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Health Information Technology (HIT)
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Related Experiment Video

Updated: Feb 14, 2026

Measuring the Time-Evolution of Nanoscale Materials with Stopped-Flow and Small-Angle Neutron Scattering
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Boron Neutron Capture Therapy: A Technology-Driven Renaissance.

Dandan Zheng1, Guang Han2, Olga Dona Maria Lemus3

  • 1Department of Radiation Oncology, University of Rochester, Rochester, NY 14627, USA.

Cancers
|February 13, 2026
PubMed
Summary
This summary is machine-generated.

Boron neutron capture therapy (BNCT) is advancing rapidly with new boron drugs, neutron sources, and imaging. This targeted radiation therapy offers a promising new option for difficult-to-treat cancers.

Keywords:
BNCTboronneutronpersonalized therapyprecision medicinetheranostics

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Boron neutron capture therapy (BNCT) is a binary targeted radiation modality.
  • Early BNCT attempts were limited by inadequate boron delivery agents and neutron sources.
  • Recent technological advancements have revitalized BNCT, making it clinically viable.

Purpose of the Study:

  • To review the recent advancements and resurgence of Boron Neutron Capture Therapy (BNCT).
  • To highlight the key technological innovations enabling modern BNCT.
  • To discuss the expanding clinical applications and future potential of BNCT.

Main Methods:

  • Review of recent technological breakthroughs in boron delivery systems (compounds, nanoparticles).
  • Analysis of advancements in accelerator-based neutron sources and theranostic approaches (PET, MRI).
  • Examination of AI-driven biodistribution modeling for personalized treatment planning.

Main Results:

  • BNCT now utilizes hospital-compatible accelerators and next-generation boron delivery systems.
  • Advanced theranostics and AI modeling support personalized treatment planning and patient selection.
  • Regulatory approvals and clinical programs are expanding globally, particularly in Asia.

Conclusions:

  • BNCT has transitioned into a commercially supported therapeutic platform with significant industrial backing.
  • Its unique hybrid nature combines targeted therapy with controllable external beam radiation.
  • BNCT shows promise for various challenging malignancies and is poised to be a transformative modality in precision oncology.