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Real-World Treatment Patterns and Survival in Patients with Advanced Non-Small Cell Lung Cancer: An Italian
Angelo Delmonte1, Nicola Gentili2, Andrea Roncadori2
1Department of Medical Oncology, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.
Real-world data show a significant shift in advanced non-small-cell lung cancer treatment, with increased use of targeted therapies and immune checkpoint inhibitors leading to improved survival outcomes.
Area of Science:
- Oncology
- Clinical Research
- Pharmacotherapy
Background:
- Advanced non-small-cell lung cancer (NSCLC) treatment has rapidly evolved.
- Real-world data are crucial for evaluating treatment patterns and effectiveness.
Purpose of the Study:
- To analyze real-world treatment patterns and outcomes for advanced NSCLC.
- To assess changes in therapy before and after new drug approvals.
Main Methods:
- Retrospective cohort study of 910 advanced NSCLC patients (2014-2021).
- Analysis of first-line therapy, overall survival (OS), and progression-free survival (PFS).
- Kaplan-Meier methods used for survival estimation.
Main Results:
- Significant increase in first-line anti-programmed death (PD)-(ligand [L])1 immune checkpoint inhibitors (ICIs) from 0% to 58%.
- Decrease in first-line platinum-based chemotherapy from 65% to 6%.
- Median OS improved from 6.0-7.4 months (2014-2017) to 8.4-15.9 months (2018-2021).
Conclusions:
- Precision targeted therapy benefits advanced NSCLC patients with specific genomic alterations.
- Immunotherapy approvals have positively impacted the advanced NSCLC treatment landscape.
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