Psychosocial Aspects of Cystic Fibrosis: A Mixed-Methods Systematic Review

Area of Science:

• Medical Research
• Psychology
• Public Health

Background:

• Cystic Fibrosis (CF) is a genetic disorder with increasing adult life expectancy.
• Growing life expectancy necessitates focus on psychosocial well-being in CF patients.
• Understanding adult psychosocial challenges in CF is crucial for comprehensive care.

Purpose of the Study:

• To systematically review and update knowledge on psychosocial aspects of living with CF in adults.
• To synthesize findings from mixed-methods research on adult CF psychosocial experiences.
• To identify key psychosocial factors affecting quality of life and survival in adult CF.

Main Methods:

• Conducted a mixed-methods systematic review following PRISMA guidelines.
• Searched multiple databases (Scopus, MEDLINE, PsycInfo, etc.) in November 2024.
• Analyzed 24 studies involving 2023 adult participants with CF.

Main Results:

• Optimistic coping correlated with improved survival in CF adults.
• High social support and gratitude linked to better treatment adherence and quality of life.
• Depression, life transition difficulties, financial stress, social stigma, and embarrassment are significant concerns.

Conclusions:

• Psychosocial factors are integral to the adult CF experience, beyond mere biological survival.
• Clinical care must integrate interventions addressing mental health and quality of life for adults with CF.
• Addressing psychosocial challenges is vital for supporting adults with CF through extended lifespans.