Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Modified Boxplots

Modified Boxplots

A standard box and whisker plot informs us about the spread of the data in a given sample. One can identify the minimum value, maximum value, first quartile value, second quartile or median value, and third quartile.
However, the box plot does not tell the reader about outliers - values that lie far from the center of the data. We can modify the standard box and whisker plot to identify the outliers and visualize the actual spread of the data in a sample.
Initially, we calculate the adjusted...

Antiasthma Drugs: Leukotriene Modifiers

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:

Lung Capacity

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.

Modified-Release Drug Delivery Systems: Bioavailability

Modified-Release Drug Delivery Systems: Bioavailability

Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...

Modified-Release Drug Delivery Systems: Overview

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

Modified-Release Drug Delivery Systems: Classification

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Barriers, facilitators and promising interventions for reducing sedentary behaviour during and after stroke rehabilitation - A scoping review.

Disability and rehabilitation·2026

Same author

Unravelling the diversity of pacing behaviours in adults with chronic conditions: a cross-sectional study.

BMJ open·2026

Same author

Factors influencing referral decisions for patients with chronic low back pain: a scoping review.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026

Same author

Cross-cultural translation and content validity of the Determinants of Physical Activity Questionnaire (DPAQ) in a Dutch stroke rehabilitation population and their peers without stroke.

Journal of patient-reported outcomes·2026

Same author

Predictors of Exercise Performance in Type 1 Diabetes: The Role of Hypoglycaemia Fear, Glycaemic Control, and Vascular Health: A Retrospective Cross-Sectional Study.

Diabetes, obesity & metabolism·2026

Same author

Differences in human assumed central sensitization between patients with radiating and non-radiating chronic low back pain: a cross-sectional observational study with special attention to sex.

Pain management·2026

Search research articles

Related Experiment Video

Updated: Feb 14, 2026

The Impact of Motor Task Conditions on Goal-Directed Arm Reaching Kinematics and Trunk Compensation in Chronic Stroke Survivors

The Impact of Motor Task Conditions on Goal-Directed Arm Reaching Kinematics and Trunk Compensation in Chronic Stroke Survivors

Published on: May 2, 2021

Modifiable and Non-Modifiable Predictors of Exercise Capacity in Stroke Survivors: A Systematic Review.

Klaske van Kammen¹, Lotte A J Verkuijlen^1,2, Ana B Nasser^1,2

¹Department of Rehabilitation Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands.

Healthcare (Basel, Switzerland)

|February 13, 2026

Summary

Modifiable factors like BMI and strength, alongside non-modifiable factors like age and diabetes, significantly predict exercise capacity in stroke survivors. Understanding these predictors aids personalized rehabilitation.

Keywords:

VO2peak body composition cardiorespiratory fitness fatigue lower limb strength personalized care rehabilitation treatment stroke systematic review training intensity

More Related Videos

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research

Published on: May 5, 2023

Whole Body Vibration Methods with Survivors of Polio

Whole Body Vibration Methods with Survivors of Polio

Published on: October 17, 2018

Related Experiment Videos

Last Updated: Feb 14, 2026

The Impact of Motor Task Conditions on Goal-Directed Arm Reaching Kinematics and Trunk Compensation in Chronic Stroke Survivors

The Impact of Motor Task Conditions on Goal-Directed Arm Reaching Kinematics and Trunk Compensation in Chronic Stroke Survivors

Published on: May 2, 2021

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research

Author Spotlight: Innovative Techniques and Future Directions in Stroke Research

Published on: May 5, 2023

Whole Body Vibration Methods with Survivors of Polio

Whole Body Vibration Methods with Survivors of Polio

Published on: October 17, 2018

Area of Science:

Rehabilitation Medicine
Cardiovascular Physiology
Neurology

Background:

Stroke survivors often experience reduced exercise capacity, impacting long-term health and recovery.
Identifying predictors of exercise capacity is crucial for optimizing rehabilitation strategies.
Understanding both modifiable and non-modifiable factors can enhance treatment personalization.

Purpose of the Study:

To systematically review and identify modifiable and non-modifiable predictors of exercise capacity (VO2peak) in stroke survivors.
To inform the optimization of rehabilitation treatments for improved long-term health outcomes.
To guide healthcare professionals in tailoring rehabilitation programs.

Main Methods:

Systematic literature search of PubMed, EMBASE, CINAHL, and Web of Science databases.
Inclusion of studies measuring VO2peak in adult stroke survivors with analyzed predictors in multivariate regression models.
Risk of bias assessment using the McMaster Critical Review Form for Quantitative Studies.

Main Results:

Seventeen articles were included, identifying significant modifiable predictors: BMI, fat mass, lower limb strength, baseline VO2peak, training intensity, and perceived fatigue.
Significant non-modifiable predictors included age, sex, diabetes, and stroke-specific factors.
These factors were shown to significantly predict VO2peak levels or changes.

Conclusions:

Both modifiable and non-modifiable predictors play a significant role in optimizing exercise capacity post-stroke.
Personalized treatment planning can be achieved by considering these diverse predictors.
Further research is recommended to develop a comprehensive prediction model for exercise capacity in stroke survivors.