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Updated: Feb 14, 2026

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
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Prognostic Value of Multimodal Cardiac Magnetic Resonance Parameters in Patients with Nondilated Left Ventricular

Chunlong Yan1, Shuang Li1, Baiyan Zhuang1

  • 1Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing 100029, China.

Journal of Clinical Medicine
|February 13, 2026
PubMed

Insights

Cardiac MRI parameters like right ventricular ejection fraction (RVEF) and left ventricular global radial strain (LVGRS) can predict major adverse cardiovascular events (MACEs) in patients with nondilated left ventricular cardiomyopathy and reduced ejection fraction.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Cardiovascular Disease

Background:

  • Nondilated left ventricular cardiomyopathy with reduced ejection fraction (NDLVC-rLVEF) presents a significant clinical challenge.
  • Predictive markers for major adverse cardiovascular events (MACEs) in this population are crucial for risk stratification.

Purpose of the Study:

  • To evaluate the predictive capability of cardiac magnetic resonance (CMR) feature parameters for MACEs in patients with NDLVC-rLVEF.
  • To identify independent risk factors for adverse outcomes in this specific patient cohort.

Main Methods:

  • Retrospective analysis of 160 patients with NDLVC-rLVEF who underwent CMR.
  • MACEs defined as cardiovascular death, ICD discharge, or hospitalization for heart failure/arrhythmia.
  • Multivariable Cox regression and Kaplan-Meier analyses were employed for risk factor identification and survival analysis.

Main Results:

  • 41 patients (25.63%) experienced MACEs during a median follow-up of 53 months.
  • Right ventricular ejection fraction (RVEF) and left ventricular global radial strain (LVGRS) emerged as independent predictors of MACEs.
  • Lower RVEF (<37%) and LVGRS (<13%) were associated with a significantly higher incidence of MACEs (p < 0.05).

Conclusions:

  • Multimodal CMR parameters, specifically RVEF and LVGRS, demonstrate significant predictive value for adverse prognosis in NDLVC-rLVEF.
  • These findings support the use of CMR-derived metrics for early risk stratification.
  • Integration of RVEF and LVGRS into clinical practice can aid in timely therapeutic interventions for high-risk patients.

Keywords:
CMR feature trackingcardiac magnetic resonancemyocardial strainnondilated left ventricular cardiomyopathyprognosis

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