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Association Between Cribriform Architecture and Lymphovascular Invasion in Prostate Cancer.

Jacqueline Chan1, Yetkin Tuac2, Okan Argun1

  • 1Department of Radiation Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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|February 13, 2026
PubMed
Summary

Cribriform architecture in prostate cancer is strongly linked to lymphovascular invasion (LVI), suggesting it indicates early disease spread. This finding helps explain the aggressive behavior of cribriform-positive tumors.

Keywords:
cribriform architecturelymphovascular invasionmicrometastatic diseaseprostate cancer

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Area of Science:

  • Oncology
  • Pathology
  • Urology

Background:

  • Cribriform architecture is an adverse histopathologic feature in prostate cancer linked to poor outcomes.
  • Cribriform-positive tumors may represent biologically non-localized disease with early dissemination.
  • Lymphovascular invasion (LVI) is a key marker of metastatic potential, but its association with cribriform morphology is unclear.

Purpose of the Study:

  • To investigate the association between cribriform morphology and LVI in prostate cancer.
  • To provide biological context for the aggressive clinical course of cribriform-positive prostate cancer.

Main Methods:

  • Retrospective analysis of 338 prostate adenocarcinoma patients undergoing radical prostatectomy.
  • Centralized pathology review for cribriform architecture assessment.
  • Multivariable logistic regression to evaluate the independent association of cribriform architecture with LVI, adjusting for Gleason score, tumor stage, and nodal status.

Main Results:

  • 28 (8.3%) patients had LVI, and 123 (36.4%) had cribriform architecture.
  • LVI was significantly more common in cribriform-positive tumors (17.9%) versus cribriform-negative tumors (2.8%; p < 0.001).
  • Cribriform architecture remained independently associated with LVI (adjusted OR, 5.20; p < 0.001).

Conclusions:

  • Cribriform architecture is strongly and independently associated with LVI in prostate cancer.
  • This association supports a biological link between cribriform morphology and early metastatic dissemination.
  • Findings suggest a need for prospective studies evaluating intensified treatment for cribriform-positive prostate cancer.