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Updated: Feb 14, 2026
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Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
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Association Between Post-COVID-19 Infection and Fibromyalgia: A Controlled Case-Control Study
1Physical Medicine and Rehabilitation Clinic, Battalgazi State Hospital, 44320 Malatya, Turkey.
Journal of Clinical Medicine
|February 13, 2026
Summary
Post-COVID-19 infection is linked to a higher chance of developing fibromyalgia, a chronic pain condition. This study used standardized criteria to assess the association between COVID-19 and fibromyalgia diagnosis.
Area of Science:
- Rheumatology
- Infectious Diseases
- Pain Medicine
Background:
- Persistent musculoskeletal pain is a growing concern post-COVID-19.
- The link between COVID-19 and fibromyalgia, diagnosed by standard criteria, requires further investigation.
Purpose of the Study:
- To examine the association between post-COVID-19 infection and fibromyalgia diagnosis using the 2016 American College of Rheumatology (ACR) criteria.
- To compare fibromyalgia prevalence in individuals with and without a history of COVID-19.
Main Methods:
- A case-control study comparing post-COVID-19 individuals with COVID-19-negative controls.
- Fibromyalgia diagnosis based on the ACR 2016 criteria.
- Exclusion of patients with ongoing symptoms suggestive of long COVID.
Main Results:
- Significantly higher fibromyalgia prevalence in the post-COVID-19 group.
- Increased odds of meeting ACR 2016 fibromyalgia criteria in post-COVID-19 individuals.
- Greater symptom burden observed in the post-COVID-19 group.
Conclusions:
- Post-COVID-19 infection is associated with an elevated risk of fibromyalgia diagnosis.
- Findings suggest considering fibromyalgia in persistent musculoskeletal pain after COVID-19.
- Further longitudinal and mechanistic research is warranted, acknowledging the observational design limitations.
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