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Related Experiment Video

Updated: Feb 14, 2026

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Hybrid Breast Reconstruction Revisited: Patient-Reported Outcomes Following Fat Grafting.

Ioan Constantin Pop1,2, Maximilian Vlad Muntean2,3, Vlad Alexandru Gata4,5

  • 1Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

Journal of Clinical Medicine
|February 13, 2026
PubMed
Summary

Hybrid breast reconstruction (HBR) combining implants and fat grafting significantly improves patient satisfaction with breast appearance and psychosocial well-being. This safe procedure enhances aesthetic outcomes and reduces physical discomfort post-mastectomy.

Keywords:
aesthetic outcomeautologous fat graftingbreast implanthybrid breast reconstructionimplant-based reconstructionlipofilling

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Area of Science:

  • Plastic Surgery
  • Reconstructive Surgery
  • Oncology

Background:

  • Hybrid breast reconstruction (HBR) integrates implant-based reconstruction with autologous fat grafting (lipofilling).
  • HBR aims to enhance aesthetic and functional outcomes after mastectomy.
  • Patient-reported outcomes are crucial for evaluating reconstructive procedures.

Purpose of the Study:

  • To evaluate patient-reported outcomes following hybrid breast reconstruction using the BREAST-Q questionnaire.
  • To assess changes in aesthetic satisfaction, physical well-being, and quality of care after lipofilling in HBR.
  • To determine the safety and efficacy of HBR with fat grafting.

Main Methods:

  • A before-after study involving 96 patients undergoing prepectoral implant-based reconstruction followed by lipofilling.
  • BREAST-Q questionnaires administered preoperatively and three months postoperatively.
  • Statistical analysis to compare pre- and postoperative outcomes across aesthetic, functional, and care domains.

Main Results:

  • Significant improvements (p < 0.01) in satisfaction with breast appearance, psychosocial well-being, sexual well-being, and overall surgical outcomes.
  • Reduction in physical symptoms like discomfort post-lipofilling.
  • High satisfaction with medical care, with no oncologic recurrences reported.

Conclusions:

  • Hybrid breast reconstruction with fat grafting significantly enhances aesthetic results and patient satisfaction.
  • The procedure offers benefits in symptom relief and is safe and effective for integration into clinical practice.
  • Careful patient selection and technique are essential for optimal outcomes in HBR.