Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Matrix-Assisted Laser Desorption Ionization (MALDI)01:08

Matrix-Assisted Laser Desorption Ionization (MALDI)

1.2K
Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and characterization of various biomolecules, including proteins, peptides, nucleic acids, and carbohydrates. MALDI is an ionization technique, widely employed in biological and medical research, as well as in fields like pharmacology and biochemistry.The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix...
1.2K
Bystander Effect02:09

Bystander Effect

10.3K
The discussion of bullying highlights the problem of witnesses not intervening to help a victim. This is a common occurrence, as the following well-publicized event demonstrates. In 1964, in Queens, New York, a 19-year-old woman named Kitty Genovese was attacked by a person with a knife near the back entrance to her apartment building and again in the hallway inside her apartment building. When the attack occurred, she screamed for help numerous times and eventually died from her stab wounds.
10.3K
Protein Complex Assembly02:41

Protein Complex Assembly

16.9K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.9K
RNA Splicing01:32

RNA Splicing

60.7K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.7K
Egoism and Altruism01:55

Egoism and Altruism

93.4K
Voluntary behavior with the intent to help other people is called prosocial behavior. Why do people help other people? Is personal benefit such as feeling good about oneself the only reason people help one another?
93.4K
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

5.8K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Benefit of adjuvant chemotherapy for resected pancreatic cancer following neoadjuvant FOLFIRINOX or Gemcitabine-Nab-paclitaxel: a multinational analysis.

Journal of the National Cancer Institute·2026
Same author

CT texture analysis and delta radiomics in predicting R0 resection after preoperative chemotherapy in resectable pancreatic ductal adenocarcinoma.

Translational oncology·2026
Same author

International consensus on mesopancreas and total mesopancreas excision (MESODELPHI).

HPB : the official journal of the International Hepato Pancreato Biliary Association·2026
Same author

Postpancreatectomy acute pancreatitis after distal pancreatectomy: tri-institutional international cohort.

BJS open·2026
Same author

Drain management after pancreatoduodenectomy: risk-stratified dynamic algorithm.

BJS open·2026
Same author

Open Total Pancreatectomy With Modified Cattell-Imanaga Reconstruction: How Do We Do It?

World journal of surgery·2026

Related Experiment Video

Updated: Feb 14, 2026

Robotic Pancreatoduodenectomy for Pancreatic Head Cancer: a Case Report of a Standardized Technique
13:38

Robotic Pancreatoduodenectomy for Pancreatic Head Cancer: a Case Report of a Standardized Technique

Published on: June 24, 2022

6.3K

From Open to Robot-Assisted Pancreatoduodenectomy: What RCTs Really Show.

Alice Cattelani1, Roberto M Montorsi1,2,3, Alessio Marchetti1

  • 1Department of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, 37134 Verona, Italy.

Journal of Clinical Medicine
|February 13, 2026
PubMed
Summary

Minimally invasive pancreatoduodenectomy (MIPD) shows comparable safety and oncological outcomes to open surgery in high-volume centers. However, benefits like reduced blood loss must be weighed against longer operative times and higher costs, especially for robotic approaches.

Keywords:
laparoscopic surgerypancreatic surgeryrobotic surgery

More Related Videos

Robot-assisted Partial Splenectomy
08:34

Robot-assisted Partial Splenectomy

Published on: January 2, 2026

641
Robot-Assisted Kidney Transplantation
07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

4.4K

Related Experiment Videos

Last Updated: Feb 14, 2026

Robotic Pancreatoduodenectomy for Pancreatic Head Cancer: a Case Report of a Standardized Technique
13:38

Robotic Pancreatoduodenectomy for Pancreatic Head Cancer: a Case Report of a Standardized Technique

Published on: June 24, 2022

6.3K
Robot-assisted Partial Splenectomy
08:34

Robot-assisted Partial Splenectomy

Published on: January 2, 2026

641
Robot-Assisted Kidney Transplantation
07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

4.4K

Area of Science:

  • Surgical Oncology
  • Gastroenterology
  • Minimally Invasive Surgery

Background:

  • Minimally invasive pancreatoduodenectomy (MIPD), including laparoscopic (LPD) and robotic (RPD), is an emerging alternative to open pancreatoduodenectomy (OPD).
  • Concerns regarding safety, reproducibility, and oncological adequacy persist despite technological advancements.
  • Randomized controlled trials (RCTs) offer high-level evidence to evaluate MIPD's true benefits and limitations.

Purpose of the Study:

  • To synthesize findings from all available RCTs comparing MIPD (LPD and RPD) with OPD.
  • To evaluate key domains including mortality, morbidity, intraoperative parameters, postoperative recovery, oncological outcomes, conversion rates, and costs.
  • To contextualize RCT findings on MIPD's benefits and limitations, rather than conduct a meta-analysis.

Main Methods:

  • Narrative review of all published RCTs comparing LPD and RPD with OPD.
  • Analysis focused on mortality, major morbidity, intraoperative blood loss (IBL), length of stay (LOS), oncological outcomes, conversion rates, and costs.
  • Consideration of surgeon experience and institutional volume's influence on outcomes.

Main Results:

  • LPD demonstrates comparable mortality and morbidity to OPD in high-volume centers, with reduced IBL and shorter LOS.
  • RPD results are mixed, with some trials showing improved recovery but others reporting higher pancreatic fistula (POPF) and delayed gastric emptying (DGE) rates, alongside increased costs.
  • Both LPD and RPD achieve equivalent oncological outcomes to OPD, with LPD showing long-term non-inferiority.
  • Operative times are longer for MIPD, and conversion rates indicate a learning curve effect.

Conclusions:

  • Current RCT evidence supports MIPD as safe, feasible, and oncologically sound in specialized, high-volume centers with experienced surgeons.
  • Benefits of reduced IBL and faster recovery must be balanced against longer operative times, conversion risks, and higher costs (especially for RPD).
  • MIPD is an advanced option requiring structured training, patient selection, and institutional readiness, not a universal standard.