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Related Concept Videos

Coping Strategies: Problem Focused01:27

Coping Strategies: Problem Focused

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Coping strategies are methods people use to manage, tolerate, or reduce the effects of stressors. These strategies involve both behavioral and psychological actions to handle stressful situations. One common approach is problem-focused coping, which aims to change or eliminate the source of stress rather than merely addressing its consequences. This method involves taking direct action to resolve the issue causing stress.
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Coping Strategies: Emotion Focused01:20

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Emotion-focused coping refers to a set of strategies aimed at managing the emotional impact of stressors, rather than directly addressing their causes. This approach involves altering one's emotional response to stressful situations to reduce their psychological effects. For example, individuals might talk with a friend or engage in activities like journaling to express their feelings. Such actions can help achieve emotional clarity or release, providing the psychological stability needed...
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During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
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Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
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Obesity01:24

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Intermittent Fasting: A Metabolically Focused Therapeutic Strategy for Obesity.

Natalia Diaz-Garrido1, Sebastián Zagmutt2, Alejandro Regaldiz3

  • 1Universidad Católica del Maule, Facultad de Ciencias de la Salud, Escuela de Nutrición y Dietética, Curicó 3340000, Chile.

Nutrients
|February 13, 2026
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Summary

Intermittent fasting (IF) shows promise for weight management and cardiovascular health by influencing thermogenesis and metabolic function. Optimal nutritional strategies during eating windows are key to maximizing the benefits of IF protocols like alternate day fasting.

Keywords:
CNS-BAT communicationalternate day fasting (ADF)brown adipose tissue (BAT)browningintermittent fasting (IF)thermogenesistime-restricted eating (TRE)

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Area of Science:

  • Nutrition Science
  • Metabolic Health
  • Cardiovascular Disease Prevention

Background:

  • Rising global obesity rates pose significant cardiovascular disease risks.
  • Novel strategies beyond pharmacology are needed for disease mitigation.
  • Intermittent fasting (IF) emerges as a popular nutritional intervention for weight management.

Purpose of the Study:

  • To compile scientific evidence on intermittent fasting (IF).
  • To explore physiological effects, thermogenic mechanisms, and refeeding strategies.
  • To analyze IF's impact on weight loss, cardiovascular health, and metabolic function.

Main Methods:

  • Narrative review of studies from PubMed/MEDLINE.
  • Analysis focused on intermittent fasting, thermogenesis, and related outcomes.
  • Examination of three common IF protocols: alternate day fasting (ADF), periodic fasting (PF), and time-restricted eating (TRE).

Main Results:

  • IF demonstrates benefits beyond weight loss, including improved cardiovascular health, reduced oxidative stress, and enhanced metabolic function.
  • The central nervous system-brown adipose tissue interaction offers a novel mechanism for thermogenesis regulation.
  • Nutritional patterns during the feeding window (proteins, fiber, bioactive compounds, essential fatty acids) are crucial for optimizing IF outcomes.

Conclusions:

  • Intermittent fasting provides a robust framework for studying energy balance.
  • IF holds significant promise for developing targeted nutritional interventions.
  • Evidence supports IF as a valuable tool for managing obesity and associated metabolic and cardiovascular risks.