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Related Experiment Video

Updated: Feb 14, 2026

Evaluating Dryocosmus Kuriphilus-induced Damage on Castanea Sativa

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Published on: August 30, 2018

Exploring Castanea sativa Shells (CSSs) as a Source of AKR1B1 and AKR1B10 Inhibitors: From Extraction to Bioactivity

Lucia Piazza^1,2, Lorena Tedeschi¹, Francesca Felice^2,3

¹Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy.

Molecules (Basel, Switzerland)

|February 13, 2026

Summary

Chestnut shells are a rich source of bioactive compounds. Processing impacts their chemical makeup and antioxidant activity, but extracts still show potential for use in a circular economy.

Keywords:

AKR inhibitors Castanea sativa shells antioxidants metabolomics

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Area of Science:

Agricultural Science
Biochemistry
Food Science

Background:

Chestnut shells are abundant industrial by-products from the food chain.
These shells contain valuable polyphenols and antioxidants.
Industrial processing may alter the shells' bioactive properties.

Purpose of the Study:

To compare the chemical composition and bioactivity of raw and processed *Castanea sativa* shells.
To understand the effects of industrial processing on chestnut shell biomass.
To evaluate chestnut shell extracts as a source of bioactive compounds for valorisation.

Main Methods:

Metabolite profiling using mass spectrometry.
Total Phenolic Index (TPI) analysis.
Assays for antioxidant capacity and inhibitory activity against AKR1B/AKR1B10 reductases.

Main Results:

Both raw and processed chestnut shells yield bioactive extracts.
Extraction solvent (water vs. ethanol) and processing status influenced extract composition and activity.
Chestnut shell extracts demonstrated antioxidant capacity and inhibitory effects on AKR1B/AKR1B10.

Conclusions:

Chestnut shell residues are a valuable source of bioactive compounds, even after industrial processing.
Extracts can potentially target oxidative stress and AKR1B/AKR1B10 activity.
Valorising chestnut shells aligns with circular economy principles.