Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Switching of BJT01:22

Switching of BJT

876
Switching behavior in Bipolar Junction Transistors (BJTs) is a fundamental aspect utilized in various electronic circuits, particularly for digital logic applications like switches and amplifiers. In a typical switching circuit, a BJT alternates between cut-off and saturation modes, corresponding to the "off" and "on" states, respectively, thus behaving like an ideal switch.
Cut-off Mode ("Off" State): In this state, both the emitter-base and collector-base junctions are...
876
Initiation of Translation02:33

Initiation of Translation

39.2K
Initiating translation is complex because it involves multiple molecules. Initiator tRNA, ribosomal subunits, and eukaryotic initiation factors (eIFs) are all required to assemble on the initiation codon of mRNA. This process consists of several steps that are mediated by different eIFs.
First, the initiator tRNA must be selected from the pool of elongator tRNAs by eukaryotic initiation factor 2 (eIF2). The initiator tRNA (Met-tRNAi) has conserved sequence elements including modified bases at...
39.2K
Initiation of Translation02:33

Initiation of Translation

8.2K
8.2K
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

1.2K
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.2K
Transcription Initiation01:47

Transcription Initiation

21.3K
Initiation is the first step of transcription in eukaryotes. Prokaryotic RNA Polymerase (RNAP) can bind to the template DNA and start transcribing. On the other hand, transcription in eukaryotes requires additional proteins, called transcription factors, to first bind to the promoter region in the DNA template. This binding helps recruit the specific RNAP that can assemble on the DNA and start transcription.
The promoters and enhancers and their accessory proteins allow tight regulation of...
21.3K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

8.8K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
8.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Na/K-ATPase α1 subunit fine-tunes platelet P2Y12 function and mediates sex dimorphism-associated thrombosis.

Blood advances·2026
Same author

HO-1 modulates obesity-related renal sodium metabolism via oxidative stress and Na/K-ATPase signaling.

Clinical science (London, England : 1979)·2025
Same author

The Na/K-ATPase α1 subunit fine-tunes platelet P2Y12 function and mediates sex dimorphism-associated thrombosis.

Blood advances·2025
Same author

INHIBITION OF THE PROSTAGLANDIN-DEGRADING ENZYME 15-PGDH AMELIORATES MASH-ASSOCIATED APOPTOSIS AND FIBROSIS IN MICE.

Cells·2025
Same author

ICU-Broncho-Aspiration Protocols Monitoring at an Academic Health Network System.

Southern medical journal·2025
Same author

Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity.

Nature communications·2025

Related Experiment Video

Updated: Feb 14, 2026

Assessment of Sexual Behavior of Male Mice
04:38

Assessment of Sexual Behavior of Male Mice

Published on: March 5, 2020

22.0K

Sexual Dimorphism in the Initial Apoptotic Switch During MASH Progression in Mice.

Pradeep K Rajan1,2, Jacqueline A Sanabria1,2, Mathew S Schade1,2

  • 1Department of Surgery, Joan C. Edwards School of Medicine, Marshall University Huntington, Huntington, WV 25701, USA.

International Journal of Molecular Sciences
|February 13, 2026
PubMed
Summary

This study reveals sexual dimorphism in MASH progression, with males showing altered redox balance and reduced apoptosis despite similar senescence levels. These findings highlight sex-specific differences in the early stages of MASH-related liver disease.

Keywords:
HCCMASHapoptosisdiet modificationmetabolismoxidative speciessenescence

More Related Videos

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice
11:16

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Published on: May 3, 2012

22.8K
Skeletal Muscle Gender Dimorphism from Proteomics
09:29

Skeletal Muscle Gender Dimorphism from Proteomics

Published on: December 14, 2011

13.0K

Related Experiment Videos

Last Updated: Feb 14, 2026

Assessment of Sexual Behavior of Male Mice
04:38

Assessment of Sexual Behavior of Male Mice

Published on: March 5, 2020

22.0K
Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice
11:16

Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice

Published on: May 3, 2012

22.8K
Skeletal Muscle Gender Dimorphism from Proteomics
09:29

Skeletal Muscle Gender Dimorphism from Proteomics

Published on: December 14, 2011

13.0K

Area of Science:

  • Hepatology
  • Metabolomics
  • Cellular Biology

Background:

  • Metabolic-associated steatohepatitis (MASH) is a progressive liver disease linked to cellular senescence and hepatocellular carcinoma (HCC).
  • Males exhibit a 2-4x higher incidence of MASH-related HCC compared to females.
  • Previous research implicated the ATP1A1 signalosome in late apoptotic switches during MASH progression.

Purpose of the Study:

  • Investigate the role of ATP1A1 and sex-specific differences in the early apoptotic switch during preclinical MASH progression.
  • Examine metabolic and molecular changes in male and female mice on a high-fat diet (HFD).

Main Methods:

  • Male and female C57BL/6J mice were fed normal chow or HFD for 12, 24, or 48 weeks.
  • Assessed total body weight, body composition (echo-MRI), plasma metabolomics (LC-MS/MS), and liver tissue for NAFLD activity scores, senescence, and apoptosis.
  • Analyzed gene expression (mTOR1, P53, Grb2, ATP1A1, survivin, SMAC) and redox balance (GSH:GSSG ratios).

Main Results:

  • Males gained more body weight and mass; exhibited altered redox balance (higher GSH:GSSG, lower ophthalmate) and distinct metabolic profiles (higher butyric acid) compared to females.
  • Males showed reduced fibrosis scores and apoptotic activity by 24 weeks, despite similar senescence levels.
  • ATP1A1, survivin, and SMAC expression did not significantly differ by sex or diet, though a trend for ATP1A1 and survivin upregulation was observed in males on HFD.

Conclusions:

  • Significant sexual dimorphism exists in the response to HFD during MASH progression, particularly in the transition from senescence to the early apoptosis-first apoptotic switch.
  • Sex-specific metabolic and redox alterations contribute to differential MASH progression pathways.