Recent Advances in Lanthanide Complexes in Biological Systems: Coordination Principles and Interactions with...

Area of Science:

• Bioinorganic Chemistry
• Coordination Chemistry
• Biomedical Applications

Background:

• Lanthanide ions and complexes possess unique photophysical, magnetic, and coordination properties.
• Their strong preference for oxygen-donor ligands, kinetic stability, and tunable luminescence enable diverse applications.

Purpose of the Study:

• To review current developments in lanthanide coordination chemistry and their interactions with biomolecules.
• To highlight design principles for complex stability, biological compatibility, and biomedical uses.
• To discuss toxicity, biodistribution, and clinical translation potential of lanthanide complexes.

Main Methods:

• Mechanistic analysis of lanthanide interactions with nucleic acids, proteins, and peptides.
• Integration of current research on lanthanide coordination chemistry.
• Synthesis of recent advances emphasizing coordination behavior and biological function.

Main Results:

• Lanthanide complexes show promise in bioimaging, sensing, therapy, and diagnostics.
• Key biomedical uses include anticancer effects, antioxidant properties, and drug delivery.
• Understanding coordination chemistry is crucial for optimizing biological performance.

Conclusions:

• Lanthanide coordination chemistry is pivotal for advancing bioinorganic research.
• Further research into complex stability and biological compatibility will enhance clinical translation.
• Emerging trends focus on the interplay between molecular coordination and biological function.