Related Experiment Video
Updated: Feb 14, 2026

Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
Predictors of Intravenous Immunoglobulin Non-Responsiveness in Children With Kawasaki Disease
1Department of Infection Diseases, Anhui Provincial Children's Hospital, Hefei, Anhui, China.
Background:
This retrospective study assesses whether the systemic immune-inflammation index (SII) is a better predictor of intravenous immunoglobulin (IVIG) non-responsiveness (IVIG-NR) in children with Kawasaki disease (KD children) than the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).
Methods:
After 458 pediatric KD patients were categorized as IVIG responders or non-responders, blood test data were collected from both groups prior to IVIG administration. Upon SII, NLR, and PLR calculation, IVIG-NR predictive performances of these markers were evaluated through receiver operating characteristic curve evaluation, and IVIG-NR risk factors (RFs) were determined by multivariate logistic regression.
Results:
Compared to IVIG responders, the non-responders showed significantly higher NLR, PLR, and SII (p-values < 0.05). The cut-off values of these markers for optimal IVIG-NR prediction were 4.245, 147.736, and 1465.238, respectively.
Conclusion:
Although all three of them were the independent RFs for IVIG-NR in KD children, SII was a better IVIG-NR predictor than NLR and PLR.
Related Concept Videos
Immunoglobulin-like Cell Adhesion Molecules
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Drug Dosing: Infants and Children
Imaging Studies V: Intravenous Urography and Retrograde Pyelography
Responses to Gravity and Touch
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...

