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Updated: Feb 14, 2026
Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy
Published on: August 19, 2021
Combined ER/PR co-positivity enhances prognostic stratification within molecular subtypes of endometrial cancer
Ruxue Han1, Yang Chen1, Shuiqing Xu1
1Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Objective:
To explore the prognostic value of combined estrogen receptor (ER)/progesterone receptor (PR) expression patterns within molecular subtypes of endometrial cancer (EC), particularly in the prognostically heterogeneous no specific molecular profile (NSMP) subtype.
Methods:
A retrospective cohort study of 388 EC patients underwent next-generation sequencing-based molecular classification and ER/PR immunohistochemistry. ER/PR status was categorized as co-positive (coP), co-negative, or discordant. Multivariable Cox models and concordance index (C-index) analyses assessed disease-specific survival (DSS) and progression-free survival (PFS).
Results:
ER/PR co-positivity independently predicted improved DSS overall (hazard ratio [HR]=0.143; 95% confidence interval [CI]=0.065, 0.314; p<0.001) after adjusting for stage and molecular subtype. In NSMP (n=254), coP predicted superior DSS (HR=0.21; 95% CI=0.06, 0.87; p=0.034), while ER positivity predicted better PFS (HR=0.13; 95% CI=0.02, 0.88; p=0.037). Adding coP to staging improved NSMP-DSS prediction (ΔC-index=+0.082; p<0.05). No significant associations were found in non-NSMP subgroups.
Conclusion:
ER/PR co-positivity is a powerful independent predictor of favorable DSS in EC, particularly refining risk stratification for the NSMP subtype when integrated with molecular classification.
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